85555
大观霉素 二盐酸盐 五水合物
≥98.0% (AT)
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经验公式（希尔记法）:
C14H24N2O7 · 2HCl · 5H2O
化学文摘社编号:
分子量:
495.35
EC Number:
244-554-3
UNSPSC Code:
51101500
PubChem Substance ID:
Beilstein/REAXYS Number:
5684150
MDL number:
InChI key
DCHJOVNPPSBWHK-UXXUFHFZSA-N
InChI
1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
SMILES string
Cl[H].Cl[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H][C@@]12O[C@H](C)CC(=O)[C@]1(O)O[C@]3([H])[C@@H](NC)[C@@H](O)[C@@H](NC)[C@H](O)[C@@]3([H])O2
biological source
synthetic
assay
≥98.0% (AT)
form
solid
color
white
solubility
H2O: 50 mg/mL, clear, faintly yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
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General description
Chemical structure: aminoglycoside
Application
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.
Preparation Note
Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.
Disclaimer
Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Corinna Kehrenberg et al.
Antimicrobial agents and chemotherapy, 51(6), 2244-2246 (2007-03-21)
Pasteurella multocida isolates with high-level spectinomycin resistance in which no adenyltransferase genes could be demonstrated exhibited a C1192G transversion in the 16S rRNA of all six or five of the six rRNA operons and/or two different types of 3-bp deletions
D Moazed et al.
Nature, 327(6121), 389-394 (1987-06-04)
Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of
Daniel Criswell et al.
Antimicrobial agents and chemotherapy, 50(2), 445-452 (2006-01-27)
We have isolated and characterized in vitro mutants of the Lyme disease agent Borrelia burgdorferi that are resistant to spectinomycin, kanamycin, gentamicin, or streptomycin, antibiotics that target the small subunit of the ribosome. 16S rRNA mutations A1185G and C1186U, homologous
Nicholas Desnoyer et al.
BMC plant biology, 20(1), 380-380 (2020-08-20)
Glycosylphosphatidylinositol (GPI) addition is one of the several post-translational modifications to proteins that increase their affinity for membranes. In eukaryotes, the GPI transamidase complex (GPI-T) catalyzes the attachment of pre-assembled GPI anchors to GPI-anchored proteins (GAPs) through a transamidation reaction.
Tarinee Tungsuchat-Huang et al.
Plant molecular biology, 76(3-5), 453-461 (2011-01-05)
Identification of a genetically stable Nicotiana tabacum (tobacco) plant with a uniform population of transformed plastid genomes (ptDNA) takes two cycles of plant regeneration from chimeric leaves and analysis of multiple shoots by Southern probing in each cycle. Visual detection
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