90469
(RS)-甲羟戊酸 锂盐
≥96.0% (GC)
别名:
(±)-MVA-Li, rac.-MVA-Li, 锂 (±)-3,5-二羟基-3-甲基-戊酸酯, 锂 (±)-3,5-二羟基-3-甲基戊酸酯
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关于此项目
经验公式（希尔记法）:
C6H11O4 · xLi+
化学文摘社编号:
分子量:
147.15 (free acid basis)
MDL number:
UNSPSC Code:
12352107
NACRES:
NA.25
Assay:
≥96.0% (GC)
Form:
solid
Biochem/physiol Actions
甲羟戊酸途径的代谢产物，在甾醇、多萜醇、血红素和泛醌的生物合成中起关键作用。在疾病肿瘤、自身免疫性疾病、动脉粥样硬化和阿尔茨海默病，以及遗传缺陷的甲羟戊酸激酶等研究领域受到关注。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Martin Thurnher et al.
Biochimica et biophysica acta, 1831(6), 1009-1015 (2013-03-26)
The mevalonate pathway is a highly conserved metabolic cascade and provides isoprenoid building blocks for the biosynthesis of vital cellular products such as cholesterol or prenyl pyrophosphates that serve as substrates for the posttranslational prenylation of numerous proteins. The pathway
Ai Hosaka et al.
Neurochemical research, 38(3), 589-600 (2012-12-28)
Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been reported to attenuate amyloid-β peptide (Aβ) production in various cellular models. However, the mechanisms by which statins affect neuronal Aβ production have not yet been clarified. Here, we investigated this issue in
Adelene Ai-Lian Song et al.
PloS one, 7(12), e52444-e52444 (2013-01-10)
Isoprenoids are a large and diverse group of metabolites with interesting properties such as flavour, fragrance and therapeutic properties. They are produced via two pathways, the mevalonate pathway or the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. While plants are the richest source of
Chitra Prasad et al.
Molecular genetics and metabolism, 107(4), 756-759 (2012-11-14)
Mevalonate kinase deficiency is a rare autosomal recessively inherited organic aciduria with a complex multi-systemic phenotype. We describe two deceased patients with clinically severe mevalonate kinase (MK) deficiency confirmed by MK mutation analysis. The phenotype in our patients ranged from
Jianxin Shi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(1), 429-435 (2012-11-28)
Esophageal squamous cell carcinoma (ESCC) is one of the most common lethal tumors in the world. Thus, it is very urgent to develop new therapeutic targets against this disease. The mevalonate (MVA) pathway, paced by its rate-limiting enzyme, hydroxymethylglutaryl coenzyme
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