91356
trans,trans-Farnesyl monophosphate ammonium salt
≥95.0% (TLC)
别名:
(E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl phosphate ammonium salt, 3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol dihydrogen phosphate ammonium salt, Farnesyl phosphate ammonium salt
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关于此项目
经验公式（希尔记法）:
C15H27O4P · xNH3
化学文摘社编号:
分子量:
302.35 (free acid basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.25
质量水平
方案
≥95.0% (TLC)
表单
powder
储存温度
−20°C
SMILES字符串
[P](=O)(OC\C=C(/CC\C=C(/CCC=C(C)C)\C)\C)(O)O
InChI
1S/C15H27O4P/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-19-20(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H2,16,17,18)/b14-9-,15-11-
InChI key
ALEWCKXBHSDCCT-FBXUGWQNSA-N
应用
Trans, trans-Farnesyl monophosphate (FMP) may be used in studies of potential endogenous modulators of nuclear lysophosphatidic acid (LPA) receptors and in the active site analysis of protein farnesyltransferase(s). Trans,trans-Farnesyl monophosphate may also be used to identify and characterize farnesyl monophosphate kinases.
生化/生理作用
Farnesyl monophosphate is a metabolite in terpenoid backbone biosynthesis. It was shown to activate PPARalpha and PPARbeta/delta reporter gene expression, indicating new potential roles for the oligoprenyl phosphates as potential endogenous modulators of LPA targets.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
M J Saderholm et al.
Biochemistry, 39(40), 12398-12405 (2000-10-04)
Protein farnesyltransferase catalyzes the posttranslational farnesylation of several proteins involved in signal transduction, including Ras, and is a target enzyme for antitumor therapies. Efficient product formation catalyzed by protein farnesyltransferase requires an enzyme-bound zinc cation and high concentrations of magnesium
Karoly Liliom et al.
Biochimica et biophysica acta, 1761(12), 1506-1514 (2006-11-10)
Oligoprenyl phosphates are key metabolic intermediates for the biosynthesis of steroids, the side chain of ubiquinones, and dolichols and the posttranslational isoprenylation of proteins. Farnesyl phosphates are isoprenoid phosphates that resemble polyunsaturated fatty alcohol phosphates, which we have recently shown
L Thai et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(23), 13080-13085 (1999-11-11)
The ability of Nicotiana tabacum cell cultures to utilize farnesol (F-OH) for sterol and sesquiterpene biosynthesis was investigated. [(3)H]F-OH was readily incorporated into sterols by rapidly growing cell cultures. However, the incorporation rate into sterols was reduced by greater than
M Bentinger et al.
Archives of biochemistry and biophysics, 353(2), 191-198 (1998-06-02)
As farnesol may serve as a nonsterol endogenous regulator of the mevalonate pathway, the possibility that a kinase specific for its phosphorylation is present in the rat liver was investigated. In the 10,000 g supernatant of rat liver, farnesyl monophosphate
I Yoshida et al.
Biochimica et biophysica acta, 995(2), 138-143 (1989-04-06)
Hexaprenyl-diphosphate synthase from Micrococcus luteus B-P 26 has been shown to comprise two essential components, designated as components A and B. Treatment of the synthase with sulphydryl reagents (N-ethylmaleimide, iodoacetamide or p-chloromercuribenzoate) or arginine-specific reagents (2,3-butanedione, 1,2-cyclohexanedione or phenylglyoxal) resulted
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