92243
胆固醇 N-（2-二甲基氨基乙基）氨基甲酸酯
≥98% (TLC)
别名:
3β-{N-[2-(二甲氨基)乙基]氨基甲酰基}膽固醇, DC-Chol
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关于此项目
经验公式（希尔记法）:
C32H56N2O2
化学文摘社编号:
分子量:
500.80
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.85
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCN(C)C
InChI
1S/C32H56N2O2/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35)/t23-,25?,26+,27-,28+,29+,31+,32-/m1/s1
InChI key
HIHOWBSBBDRPDW-MTIZRNOUSA-N
assay
≥98% (TLC)
form
powder or crystals
functional group
ester
storage temp.
−20°C
Quality Level
Application
- 白细胞介素6在阳离子脂质体诱导抗原特异性粘膜免疫球蛋白A中的作用。：本研究探讨了在阳离子脂质体中使用胆固醇N-(2-二甲基氨基乙基)氨基甲酸酯促进粘膜免疫球蛋白A的产生，突出了其在疫苗开发中的潜力（Tada et al., 2021）。
- 鼻腔联合接种肺炎球菌表面蛋白A以及DOTAP和DC-chol组成的阳离子脂质体，可使小鼠获得抗原介导的抗肺炎链球菌感染的保护性免疫。：这项研究证实了胆固醇N-(2-二甲基氨基乙基)氨基甲酸酯在鼻腔疫苗中的效力，为预防呼吸道感染提供了一种有前景的策略（Tada et al., 2018）。
Biochem/physiol Actions
阳离子脂质体，在癌症基因治疗中进行研究，作为疫苗递送系统/佐剂。
Packaging
无底玻璃瓶。内含物装在锥底内插管中。
hcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Malou Henriksen-Lacey et al.
Molecular pharmaceutics, 8(1), 153-161 (2010-12-02)
The immunostimulatory capacities of cationic liposomes are well-documented and are attributed both to inherent immunogenicity of the cationic lipid and more physical capacities such as the formation of antigen depots and antigen delivery. Very few studies have however been conducted
Gene therapy using DC-Chol liposomes.
Goyal, K. and Huang, L.
Journal of liposome research, 5, 49-60 (1995)
Francesco Cardarelli et al.
Molecular pharmaceutics, 9(2), 334-340 (2011-12-27)
Here we investigate the cellular uptake mechanism and final intracellular fate of two cationic liposome formulations characterized by similar physicochemical properties but very different lipid composition and efficiency for intracellular delivery of DNA. The first formulation is made of cationic
Jie Gao et al.
Biomaterials, 31(9), 2655-2664 (2009-12-29)
The development of a tumor-specific immunoliposome delivering small interfering RNA (siRNA) represents a practical way in cancer gene therapy. In this study, we developed PEGylated 3beta-[N-(N', N'-dimethylaminoethane) carbamoyl] cholesterol (DC-Chol)/dioleoylphosphatidyl ethanolamine (DOPE) immunoliposomes conjugated with the Fab' of recombinant humanized
Emmanuel A Ho et al.
Journal of pharmaceutical sciences, 99(6), 2839-2853 (2010-01-22)
Cationic liposomes exhibit a propensity to selectively target tumor-associated blood vessels demonstrating potential value as anti-cancer drug delivery vehicles. Their utility however, is hampered by their biological instability and rapid elimination following i.v. administration. Efforts to circumvent rapid plasma elimination
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