92243
胆固醇 N-（2-二甲基氨基乙基）氨基甲酸酯
≥98% (TLC)
别名:
3β-{N-[2-(二甲氨基)乙基]氨基甲酰基}膽固醇, DC-Chol
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关于此项目
经验公式（希尔记法）:
C32H56N2O2
化学文摘社编号:
分子量:
500.80
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.85
产品名称
胆固醇 N-（2-二甲基氨基乙基）氨基甲酸酯, ≥98% (TLC)
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCN(C)C
InChI
1S/C32H56N2O2/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35)/t23-,25?,26+,27-,28+,29+,31+,32-/m1/s1
InChI key
HIHOWBSBBDRPDW-MTIZRNOUSA-N
assay
≥98% (TLC)
form
powder or crystals
functional group
ester
storage temp.
−20°C
Quality Level
Application
- 白细胞介素6在阳离子脂质体诱导抗原特异性粘膜免疫球蛋白A中的作用。：本研究探讨了在阳离子脂质体中使用胆固醇N-(2-二甲基氨基乙基)氨基甲酸酯促进粘膜免疫球蛋白A的产生，突出了其在疫苗开发中的潜力（Tada et al., 2021）。
- 鼻腔联合接种肺炎球菌表面蛋白A以及DOTAP和DC-chol组成的阳离子脂质体，可使小鼠获得抗原介导的抗肺炎链球菌感染的保护性免疫。：这项研究证实了胆固醇N-(2-二甲基氨基乙基)氨基甲酸酯在鼻腔疫苗中的效力，为预防呼吸道感染提供了一种有前景的策略（Tada et al., 2018）。
Biochem/physiol Actions
阳离子脂质体，在癌症基因治疗中进行研究，作为疫苗递送系统/佐剂。
Packaging
无底玻璃瓶。内含物装在锥底内插管中。
hcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xing et al.
Advanced drug delivery reviews, 30(1-3), 219-227 (2000-06-06)
Cationic liposomes have been used in many gene therapy approaches. The advantages of low toxicity, lack of immunological response, and easy preparation using cationic liposomes make multiple administrations possible, which may overcome the disadvantage of low transfection efficiency. Cationic liposomes
Dennis Christensen et al.
Expert review of vaccines, 10(4), 513-521 (2011-04-22)
The application of cationic liposomes as vaccine delivery systems and adjuvants has been investigated extensively over the last few decades. However, cationic liposomes are, in general, not sufficiently immunostimulatory, which is why the combination of liposomes with immunostimulating ligands has
Rui Tada et al.
Molecular pharmaceutics, 15(9), 4226-4234 (2018-08-16)
Infections remain a major threat to human lives. To overcome the threat caused by pathogens, mucosal vaccines are considered a promising strategy. However, no inactivated and/or subunit mucosal vaccine has been approved for human use, largely because of the lack
Yang Zhang et al.
International journal of pharmaceutics, 390(2), 198-207 (2010-02-02)
Cationic liposomes (CLs) composed of 3beta-[N-(N',N'-dimethylaminoethane) carbamoyl] cholesterol (DC-Chol) and dioleoylphosphatidylethanolamine (DOPE) (DC-Chol/DOPE liposomes) have been classified as one of the most efficient gene delivery systems. Our study aims to examine the effect of the molar ratio of DC-Chol/DOPE, PEGylation
Minghan Shi et al.
Journal of nanobiotechnology, 16(1), 77-77 (2018-10-07)
Effectiveness of chemotherapy for treating glioblastoma (GBM) brain tumors is hampered by the blood-brain barrier which limits the entry into the brain of most drugs from the blood. To bypass this barrier, convection-enhanced delivery (CED) was proposed to directly inject
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