92243
胆固醇 N-（2-二甲基氨基乙基）氨基甲酸酯
≥98% (TLC)
别名:
3β-{N-[2-(二甲氨基)乙基]氨基甲酰基}膽固醇, DC-Chol
质量水平
方案
≥98% (TLC)
表单
powder or crystals
官能团
ester
储存温度
−20°C
SMILES字符串
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCN(C)C
InChI
1S/C32H56N2O2/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35)/t23-,25?,26+,27-,28+,29+,31+,32-/m1/s1
InChI key
HIHOWBSBBDRPDW-MTIZRNOUSA-N
应用
- 白细胞介素6在阳离子脂质体诱导抗原特异性粘膜免疫球蛋白A中的作用。：本研究探讨了在阳离子脂质体中使用胆固醇N-(2-二甲基氨基乙基)氨基甲酸酯促进粘膜免疫球蛋白A的产生，突出了其在疫苗开发中的潜力（Tada et al., 2021）。
- 鼻腔联合接种肺炎球菌表面蛋白A以及DOTAP和DC-chol组成的阳离子脂质体，可使小鼠获得抗原介导的抗肺炎链球菌感染的保护性免疫。：这项研究证实了胆固醇N-(2-二甲基氨基乙基)氨基甲酸酯在鼻腔疫苗中的效力，为预防呼吸道感染提供了一种有前景的策略（Tada et al., 2018）。
生化/生理作用
阳离子脂质体，在癌症基因治疗中进行研究，作为疫苗递送系统/佐剂。
包装
无底玻璃瓶。内含物装在锥底内插管中。
危险声明
危险分类
Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Malou Henriksen-Lacey et al.
Molecular pharmaceutics, 8(1), 153-161 (2010-12-02)
The immunostimulatory capacities of cationic liposomes are well-documented and are attributed both to inherent immunogenicity of the cationic lipid and more physical capacities such as the formation of antigen depots and antigen delivery. Very few studies have however been conducted
Francesco Cardarelli et al.
Molecular pharmaceutics, 9(2), 334-340 (2011-12-27)
Here we investigate the cellular uptake mechanism and final intracellular fate of two cationic liposome formulations characterized by similar physicochemical properties but very different lipid composition and efficiency for intracellular delivery of DNA. The first formulation is made of cationic
Gene therapy using DC-Chol liposomes.
Goyal, K. and Huang, L.
Journal of liposome research, 5, 49-60 (1995)
Xing et al.
Advanced drug delivery reviews, 30(1-3), 219-227 (2000-06-06)
Cationic liposomes have been used in many gene therapy approaches. The advantages of low toxicity, lack of immunological response, and easy preparation using cationic liposomes make multiple administrations possible, which may overcome the disadvantage of low transfection efficiency. Cationic liposomes
Minghan Shi et al.
Journal of nanobiotechnology, 16(1), 77-77 (2018-10-07)
Effectiveness of chemotherapy for treating glioblastoma (GBM) brain tumors is hampered by the blood-brain barrier which limits the entry into the brain of most drugs from the blood. To bypass this barrier, convection-enhanced delivery (CED) was proposed to directly inject
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