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A002

N⁶-Cyclohexyladenosine

Name: N<SUP>6</SUP>-Cyclohexyladenosine
Brand: SIGMA

别名:

CHA

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关于此项目

经验公式（希尔记法）:

C₁₆H₂₃N₅O₄

化学文摘社编号:

36396-99-3

分子量:

349.38

UNSPSC Code:

12352204

PubChem Substance ID:

329770564

MDL number:

MFCD00036808

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属性

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCCC4)ncnc23

InChI

1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1

InChI key

SZBULDQSDUXAPJ-XNIJJKJLSA-N

说明

General description

N^6-Cyclohexyladenosine belongs to the class of new generation thermolytic agents.

Biochem/physiol Actions

N⁶-Cyclohexyladenosine is an adenosine A1 receptor agonist. It prevents thermogenesis and other response such as shivering in response to cold. N⁶-Cyclohexyladenosine initiates hibernation in animals.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine

Crosson CE, et al.

Investigative Ophthalmology & Visual Science, 46(10), 3795-3799 (2005)

Precise Control of Target Temperature Using N6-Cyclohexyladenosine and Real-Time Control of Surface Temperature

Laughlin BW, et al.

Therapeutic hypothermia and temperature management, 8(2), 108-116 (2018)

Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons.

Matthew Edward Pamenter et al.

Brain research, 1213, 27-34 (2008-05-06)

Adenosine is a defensive metabolite that is critical to anoxic neuronal survival in the freshwater turtle. Channel arrest of the N-methyl-d-aspartate receptor (NMDAR) is a hallmark of the turtle's remarkable anoxia tolerance and adenosine A1 receptor (A1R)-mediated depression of normoxic

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