A0760
L -氮杂环丁烷-2-羧酸
≥99%
别名:
( S )-氮杂环丁烷-2-羧酸
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选择尺寸
关于此项目
经验公式（希尔记法）:
C4H7NO2
化学文摘社编号:
分子量:
101.10
UNSPSC Code:
12352209
NACRES:
NA.32
PubChem Substance ID:
EC Number:
218-362-5
Beilstein/REAXYS Number:
80680
MDL number:
Assay:
≥99%
Form:
powder
Quality Level
assay
≥99%
form
powder
SMILES string
OC(=O)[C@@H]1CCN1
InChI
1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1
InChI key
IADUEWIQBXOCDZ-VKHMYHEASA-N
General description
L -氮杂环丁烷-2-羧酸是一种非蛋白氨基酸和致畸剂。它是有毒的。
Application
L -氮杂环丁烷-2-羧酸已被用作液相色谱-质谱法中的标准品：
- 胶原合成抑制剂
- 蛋白折叠拮抗剂
Biochem/physiol Actions
在干扰新生蛋白折叠时，氮杂环丁烷-2-羧酸 (AZC) 触发蛋白聚集或上调易于聚集的突变蛋白的表达。
L-氮杂环丁烷-2-羧酸是胶原合成抑制剂，具有抗血管生成作用。
L-氮杂环丁烷-2-羧酸是胶原合成抑制剂，具有抗血管生成作用。它是 L-脯氨酸的四元环类似物，当掺入它而不是脯氨酸时导致蛋白质错构。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Azetidine-2-carboxylic acid in garden beets (Beta vulgaris)
Rubenstein E, et al.
Phytochemistry, 67(9), 898-903 (2006)
Asmita Ghosh et al.
Cellular and molecular life sciences : CMLS, 76(8), 1605-1621 (2019-01-27)
The proteostasis network (PN) comprises a plethora of proteins that are dedicated to aid in protein folding and maintenance; some with overlapping functions. Despite this, there are multiple pathophysiological states associated with depletion of chaperones. This is counter-intuitive, assuming cells
Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness
Tye B, et al.
eLife, 8(9), e43002-e43002 (2019)
Essential function of Mec1, the budding yeast ATM/ATR checkpoint-response kinase, in protein homeostasis
Corcoles-Saez I, et al.
Developmental Cell, 46(4), 495-503 (2018)
Nadinath B Nillegoda et al.
Molecular biology of the cell, 21(13), 2102-2116 (2010-05-14)
Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae Ubr1 and Ubr2 ubiquitin ligases promote degradation of unfolded or misfolded cytosolic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A0760-1G | 04061826731598 |
| A0760-100MG | 04061833626955 |
| A0760-250MG | 04061833616109 |
| A0760-50MG | 04061833456118 |
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