A1388
腺苷5′-[γ-硫代]三磷酸盐 四锂盐
≥75% (HPLC), synthetic (organic), powder
别名:
ATP-γ-S, Ado-5′-PPP[S], 腺苷5′-（3-硫代三磷酸盐） 四锂盐
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关于此项目
经验公式（希尔记法）:
C10H12Li4N5O12P3S
化学文摘社编号:
分子量:
546.98
NACRES:
NA.51
PubChem Substance ID:
eCl@ss:
32160414
UNSPSC Code:
41106305
EC Number:
298-862-8
MDL number:
Beilstein/REAXYS Number:
6265083
Assay:
≥75% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
H2O: 25 mg/mL
Storage temp.:
−20°C
产品名称
腺苷5′-[γ-硫代]三磷酸盐 四锂盐, ≥75% (HPLC), powder
InChI key
DWQFDOIBOYDYKH-KWIZKVQNSA-J
InChI
1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
SMILES string
[Li+].[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
biological source
synthetic (organic)
assay
≥75% (HPLC)
form
powder
color
off-white
solubility
H2O: 25 mg/mL
shipped in
dry ice
storage temp.
−20°C
Quality Level
Application
腺苷5′-[γ-硫代]三磷酸腺苷四锂盐已用于处理花粉粒，测定三磷酸腺苷（ATP）或其水解产物的抑制作用。它还用于筛选硫代磷酸酯靶蛋白。
Biochem/physiol Actions
腺苷5′-[γ-硫代]三磷酸(ATP-γ-S)是一种广泛使用的非水解ATP类似物，用于研究包括细胞外功能等多种过程中ATP结合ATP位点的影响。ATP- γ-S是一种P2嘌呤能激动剂，能够增强Ca2+-活化 K+通道活性。 ATP- γ-S能够在激酶反应中取代ATP，生成硫代磷酸化蛋白，耐受蛋白磷酸酶，调节泛素偶联物和26S蛋白酶体结合的ATP依赖性步骤。 ATP-γ -S可差分调节Toll样受体4介导的细胞存活和死亡。
Other Notes
非水解ATP类似物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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In the eukaryotic 26S proteasome, the 20S particle is regulated by six AAA ATPase subunits and, in archaea, by a homologous ring complex, PAN. To clarify the role of ATP in proteolysis, we studied how nucleotides bind to PAN. Although
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Xiang Chen et al.
STAR protocols, 2(1), 100278-100278 (2021-02-02)
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