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A5835

γ-氨基丁酸

≥99%, suitable for ligand binding assays, BioXtra

别名:

3-羧丙胺, 4-氨基丁酸, GABA, 哌啶酸, 氨酪酸

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关于此项目

线性分子式:
NH2(CH2)3COOH
化学文摘社编号:
56-12-2
分子量:
103.12
NACRES:
NA.26
PubChem Substance ID:
24891025
UNSPSC Code:
12352106
EC Number:
200-258-6
MDL number:
MFCD00008226
Beilstein/REAXYS Number:
906818
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产品名称

γ-氨基丁酸, BioXtra, ≥99%

product line

BioXtra

Quality Level

200

assay

≥99%

form

powder

technique(s)

ligand binding assay: suitable

impurities

<0.0005% Phosphorus (P), <0.1% Insoluble matter

ign. residue

<0.1%

color

white

mp

195 °C (dec.) (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): <0.04%, sulfate (SO42-): <0.05%

cation traces

Al: <5 mg/kg, Ca: <20 mg/kg, Cu: <5 mg/kg, Fe: <5 mg/kg, K: <50 mg/kg, Mg: <50 mg/kg, NH4+: <500 mg/kg, Na: <70 mg/kg, Pb: <10 mg/kg, Zn: <5 mg/kg

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

Gene Information

human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Gabra1(29705), Gabra2(29706), Olr1750(294204), Slc6a1(79212), Slc6a12(50676)

General description

γγ-氨基丁酸(GABA)是一种与大脑有关的非蛋白质氨基酸。在神经系统中合成，贮存于突触囊泡中。天然存在于绿茶、大豆、发芽稻米和一些发酵食品中。

Application

γγ-氨基丁酸(GABA)已用于处理背根神经节神经元进行电生理记录研究，以研究其对大鼠神经病理性疼痛的影响。它还用于检测其在小体积移植(SFSG)损伤模型的离体机械灌注系统中的保护作用。

Biochem/physiol Actions

大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。
γγ-氨基丁酸（GABA）是一种哺乳动物抑制性神经递质，具有多种功能。它对于中枢神经系统(CNS)的正常功能发挥至关重要。文献记录的GABA功能包括它在毒素诱导损伤中的保护作用。它还具有抗高血压、抗糖尿、抗微生物、抗氧化、抗过敏、抗炎和抗癌作用。GABA可能有益于人的压力和睡眠改善。γγ-氨基丁酸(GABA)可用于研究由GABA受体——GABAA和GABAB——介导的生物和生化过程。

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存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCD3795
BCBT6042
BCBZ1867
BCBT8658
BCBR3355V

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Piril Hepsomali et al.
Frontiers in neuroscience, 14, 923-923 (2020-10-13)
Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role
Dai-Hung Ngo et al.
Molecules (Basel, Switzerland), 24(15) (2019-07-28)
Gamma-aminobutyric acid (Gaba) is a non-proteinogenic amino acid that is widely present in microorganisms, plants, and vertebrates. So far, Gaba is well known as a main inhibitory neurotransmitter in the central nervous system. Its physiological roles are related to the
Li-Jie Wang et al.
Experimental and therapeutic medicine, 14(2), 1373-1380 (2017-08-16)
Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess
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全球贸易项目编号

货号GTIN
A5835-10G04061833376522
A5835-10MG04061833617021
A5835-100G04061833376515
A5835-25G04061833376539