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A6677

Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro

Name: Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro
Brand: SIGMA

synthetic (organicorganic), ≥97% (HPLC), fibronectin binding inhibitor, powder

别名:

Arginyl-Glycyl-Asparagyl-Serinyl-Prolyl-Alaninyl-Serinyl-Serinyl-Lysyl-Proline, RGDSPASSKP

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关于此项目

经验公式（希尔记法）:

C₄₀H₆₈N₁₄O₁₆

化学文摘社编号:

91575-25-6

分子量:

1001.05

UNSPSC Code:

12352202

PubChem Substance ID:

24891126

NACRES:

NA.77

MDL number:

MFCD00076453

Form:

powder

Assay:

≥97% (HPLC)

Biological source:

synthetic (organic
organic)

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属性

产品名称

Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro, ≥97% (HPLC)

biological source

synthetic (organic
organic)

Quality Level

200

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P02751

storage temp.

−20°C

SMILES string

CC(NC(=O)C1CCCN1C(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(N)CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)N2CCCC2C(O)=O

InChI

1S/C40H68N14O16/c1-20(31(61)50-24(17-55)35(65)51-25(18-56)34(64)49-22(8-2-3-11-41)37(67)54-14-6-10-28(54)39(69)70)47-36(66)27-9-5-13-53(27)38(68)26(19-57)52-33(63)23(15-30(59)60)48-29(58)16-46-32(62)21(42)7-4-12-45-40(43)44/h20-28,55-57H,2-19,41-42H2,1H3,(H,46,62)(H,47,66)(H,48,58)(H,49,64)(H,50,61)(H,51,65)(H,52,63)(H,59,60)(H,69,70)(H4,43,44,45)

InChI key

JMBLPSUDFRAOLU-UHFFFAOYSA-N

Gene Information

human ... FN1(2335)

说明

Application

Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro has been used to test its effect on the adhesion of Hemophilus somnus in bovine brain endothelial cells.

Biochem/physiol Actions

Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro peptide comprises the RGD sequence and blocks β2-integrin-binding sites.

Inhibits fibronectin binding to fibroblasts.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000464681

0000448031

0000446391

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Roles of cellular activation and sulfated glycans in Haemophilus somnus adherence to bovine brain microvascular endothelial cells.

E Behling-Kelly et al.

Infection and immunity, 74(9), 5311-5318 (2006-08-24)

Haemophilus somnus can cause a devastating fibrinopurulent meningitis with thrombotic vasculitis and encephalitis in cattle. The mechanisms used by H. somnus to migrate from the bloodstream into the central nervous system (CNS) are unknown. In this study, we demonstrate that

A new strategy to reduce amyloid deposition using peptide-imprinted membranes.

Caterina Cristallini et al.

Journal of applied biomaterials & functional materials, 14(2), e129-e136 (2016-04-09)

The accumulation of amyloid beta protein in the brain causes the cognitive impairment observed in neurodegenerative pathologies such as Alzheimer's disease. The present study aimed to test the hypothesis that a rapid removal of amyloid beta protein peptides from the

Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function.

K M Yamada et al.

The Journal of cell biology, 99(1 Pt 1), 29-36 (1984-07-01)

Fibronectin and certain polypeptide regions of this adhesive glycoprotein mediate cell attachment and spreading on various substrates. We explored the theoretical prediction that this adhesive protein could become a competitive inhibitor of fibronectin-mediated processes if present in solution at appropriately

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全球贸易项目编号

货号	GTIN
A6677-1MG	04061826731710