AV44721
Anti-LOC203547 antibody produced in rabbit
IgG fraction of antiserum
别名:
Anti-Hypothetical protein LOC203547, Anti-MGC125514, Anti-MGC125516, Anti-MGC131652
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Technique(s):
western blot: suitable, immunohistochemistry: suitable
Conjugate:
unconjugated
Application:
IHC, WB
Citations:
2
technique(s)
western blot: suitable, immunohistochemistry: suitable
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
11 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LOC203547(203547)
Immunogen
Synthetic peptide directed towards the N terminal region of human LOC203547
Application
Anti-LOC203547 antibody produced in rabbit is suitable for western blotting at a concentration of 5.0μg/ml and for immunohistochemistry of paraffin-embedded tissue sections at a concentration of 4-8μg/ml.
Biochem/physiol Actions
The protein encoded by LOC203547 is VMA21 vacuolar H+-ATPase homolog (VMA21), a chaperone for the assembly of lysosomal vacuolar ATPase, the major proton pump of cellular membrane in mammals. Mutations in VMA21 gene causes X-linked myopathy with excessive cell vacuolation, autophagy and tissue atrophy.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: MERPDKAALNALQPPEFRNESSLASTLKTLLFFTALMITVPIGLYFTTKS
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Michio Hirano et al.
Cell, 137(2), 213-215 (2009-04-22)
The Vma21p protein in yeast is an essential assembly chaperone for the vacuolar ATPase, the major proton pump of cellular membranes. In this issue, Ramachandran et al. (2009) report that mutations in the gene encoding the human homolog VMA21 cause
Nivetha Ramachandran et al.
Acta neuropathologica, 125(3), 439-457 (2013-01-15)
X-linked Myopathy with Excessive Autophagy (XMEA) is a childhood onset disease characterized by progressive vacuolation and atrophy of skeletal muscle. We show that XMEA is caused by hypomorphic alleles of the VMA21 gene, that VMA21 is the diverged human ortholog
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