B5311
盐酸比哌立登 盐酸盐
≥98% (HPLC), powder
别名:
1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride, Akineton, Akinophyl
Quality Level
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
DMSO: >20 mg/mL, H2O: insoluble
originator
Abbott
SMILES string
Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4
InChI
1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H
InChI key
RDNLAULGBSQZMP-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128)
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Biochem/physiol Actions
Antiparkinsonian; non-selective muscarinic receptor antagonist.
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder.
Lúcio Botelho-Nogueira et al.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 33(4), 412-413 (2011-12-23)
Marina S Zacarias et al.
Neuroscience letters, 513(2), 129-131 (2012-02-18)
It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and
Elmorsy Khaled et al.
Talanta, 87, 40-45 (2011-11-22)
The construction and performance characteristics of Biperiden (BP) polyvinyl chloride (PVC) electrodes are described. Different methods for electrode fabrication are tested including; incorporation of BP-ion pairs (BP-IPs), incorporation of ion pairing agents, or soaking the plain electrode in BP-ion pairs
Ivana S Abalos et al.
Environmental toxicology and pharmacology, 34(2), 223-227 (2012-05-05)
The aim of this research has been to determine the biperiden hydrochloride permeability in Caco-2 model, in order to classify it based on the Biopharmaceutics Classification System (BCS). The World Health Organization (WHO) as well as many other authors have
E Falidas et al.
Il Giornale di chirurgia, 32(8-9), 368-371 (2011-10-25)
Stercoral perforation of the colon due to fecaloma is a rare disease and less than 100 cases have been described in the literature. The disease mainly involves the rectosigmoid colon. The condition is correlated with longstanding decubitus, chronic constipation, abuse
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B5311-10MG | 04061832079363 |
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