B7272
4-溴钙离子载体A23187
apoptosis inhibitor, powder
别名:
4-溴-A23187, 4-溴-钙霉素
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关于此项目
经验公式（希尔记法）:
C29H36BrN3O6
化学文摘社编号:
分子量:
602.52
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Quality level:
产品名称
4-溴钙离子载体A23187, powder
form
powder
Quality Level
color
yellow
solubility
ethanol: 20 mg/mL, DMSO: soluble
storage temp.
2-8°C
SMILES string
CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O
InChI
1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
InChI key
LDXQFZZGVTWFCF-FHYGWRBKSA-N
Application
4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.
非荧光Ca2+离子载体，可用于通过荧光探针校准细胞质游离Ca2+的定量。
Biochem/physiol Actions
4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.
Other Notes
Analog of calcium ionophore A23187
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signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Kinetics of endogenous CaMKII required for synaptic plasticity revealed by optogenetic kinase inhibitor.
Murakoshi H, et al.
Neuron, 94(1), 37-47 (2017)
Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons.
Kim HJ, et al.
Experimental & Molecular Medicine, 39(5), 574-574 (2007)
Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.
Whyte MK, et al.
The Journal of Clinical Investigation, 92(1), 446-455 (1993)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B7272-1MG | 04061833441671 |