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关于此项目
经验公式(希尔记法):
C11H13N3O · C4H4O4
化学文摘社编号:
分子量:
319.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
H2O: 10 mg/mL
storage temp.
−20°C
SMILES string
OC(=O)\C=C/C(O)=O.NCCc1c[nH]c2ccc(cc12)C(N)=O
InChI
1S/C11H13N3O.C4H4O4/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10;5-3(6)1-2-4(7)8/h1-2,5-6,14H,3-4,12H2,(H2,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
PZQZSWAOVAMBQM-BTJKTKAUSA-N
Gene Information
human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR2A(3356), HTR2C(3358), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
rat ... Htr7(65032)
Biochem/physiol Actions
5-HT1A,5-HT1B,5-HT1D,5-HT5和5-HT7血清素受体的激动剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Ayako Moritomo et al.
Bioorganic & medicinal chemistry, 22(15), 4323-4337 (2014-06-12)
We previously reported that the novel dual 5-HT₂B and 5-HT7 receptor antagonist N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (4) exerted a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs. To develop a synthetic strategy, we performed docking studies of lead compound 4 bound
Kirsten E Hoff et al.
PloS one, 13(8), e0203198-e0203198 (2018-08-30)
Mutations in mitochondrial DNA (mtDNA) have been linked to a variety of metabolic, neurological and muscular diseases which can present at any time throughout life. MtDNA is replicated by DNA polymerase gamma (Pol γ), twinkle helicase and mitochondrial single-stranded binding
W L Bacon et al.
The Journal of pharmacology and experimental therapeutics, 294(2), 672-679 (2000-07-20)
The 5-hydroxytryptamine(7) (5-HT(7)) receptor was originally defined by molecular biology techniques. The 5-HT(7) receptor protein and mRNA are found in brain areas, such as the CA3 subfield of the hippocampus, that are involved in various neuropsychiatric disease states. No functional
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C117-25MG | 04061832081342 |
| C117-5MG | 04061832081359 |
