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C1511

Colistin sodium methanesulfonate

Name: Colistin sodium methanesulfonate
Brand: SIGMA

~11,500 U/mg

别名:

Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate

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经验公式（希尔记法）:

C₅₈H₁₁₅N₁₆Na₅O₂₈S₅

化学文摘社编号:

8068-28-8

分子量:

1759.90

NACRES:

NA.85

PubChem Substance ID:

24892418

UNSPSC Code:

51102829

EC Number:

232-516-9

MDL number:

MFCD00130824

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form

powder

Quality Level

200

specific activity

~11,500 U/mg

solubility

H₂O: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O

InChI

1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1

InChI key

WSDSONZFNWDYGZ-BKFDUBCBSA-I

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General description

Chemical structure: peptide

Application

Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.

Biochem/physiol Actions

Colistin is a cationic, multicomponent lipopeptide antibiotic. It consists of a cyclic heptapeptide with tripeptide side chain, acylated at the N terminus by a fatty acid. It exhibits a potent anti-endotoxin. Colistin interacts with the anionic LPS molecules and displaces calcium and magnesium ions. It solubilzes the cytoplasmic membrane resulting in leakage of cytosol which contributes to the bactericidal effect.

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000462291

0000424099

0000397389

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Colistin and polymyxin B: a re-emergence.

Sachin Gupta et al.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 13(2), 49-53 (2009-11-03)

One of the greatest achievements of modern medicine is the development of antibiotics against life-threatening infections, but the emergence of multidrug-resistant (MDR) gram negative bacteria has drastically narrowed down the therapeutic options against them. This limitation has led clinicians to

Potential of old-generation antibiotics to address current need for new antibiotics.

Matthew E Falagas et al.

Expert review of anti-infective therapy, 6(5), 593-600 (2008-10-14)

Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent years. Presented with the significant problem of advancing antimicrobial resistance, the global scientific community has attempted to find alternative

Steady-state pharmacokinetics and BAL concentration of colistin in critically Ill patients after IV colistin methanesulfonate administration.

Roberto Imberti et al.

Chest, 138(6), 1333-1339 (2010-06-19)

Infections caused by multidrug-resistant gram-negative bacteria have caused a resurgence of interest in colistin. To date, information about pharmacokinetics of colistin is very limited in critically ill patients, and no attempts have been made to evaluate its concentration in BAL.

Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers.

W Couet et al.

Clinical pharmacology and therapeutics, 89(6), 875-879 (2011-05-06)

Colistin pharmacokinetics (PK) was investigated in young healthy volunteers after a 1-h infusion of 80 mg (1 million international units (MIU)) of the prodrug colistin methanesulfonate (CMS). Concentration levels of CMS and colistin were determined in plasma and urine using

Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients.

S M Garonzik et al.

Antimicrobial agents and chemotherapy, 55(7), 3284-3294 (2011-05-11)

With increasing clinical emergence of multidrug-resistant Gram-negative pathogens and the paucity of new agents to combat these infections, colistin (administered as its inactive prodrug colistin methanesulfonate [CMS]) has reemerged as a treatment option, especially for critically ill patients. There has

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全球贸易项目编号

货号	GTIN
C1511-10MU	04061833467688
C1511-100MU	04061833467671

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主要文件

Colistin sodium methanesulfonate

~11,500 U/mg

选择尺寸

关于此项目

属性

form

Quality Level

specific activity

solubility

antibiotic activity spectrum

mode of action

storage temp.

SMILES string

InChI

InChI key

相关类别

说明

General description

Application

Biochem/physiol Actions

Other Notes

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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