D1529
2,4-二硝基氟苯
≥99%
别名:
2,4-二硝基-1-氟苯, DNFB, DNPF, FDNB, 桑格试剂
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线性分子式:
(O2N)2C6H3F
化学文摘社编号:
分子量:
186.10
UNSPSC Code:
12352204
NACRES:
NA.83
PubChem Substance ID:
EC Number:
200-734-3
Beilstein/REAXYS Number:
398632
MDL number:
Quality Level
assay
≥99%
form
solid
refractive index
n20/D 1.569 (lit.)
bp
178 °C/25 mmHg (lit.)
mp
25-27 °C (lit.)
density
1.482 g/mL at 25 °C (lit.)
storage temp.
room temp
SMILES string
[O-][N+](=O)c1ccc(F)c(c1)[N+]([O-])=O
InChI
1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
InChI key
LOTKRQAVGJMPNV-UHFFFAOYSA-N
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General description
1-氟-2，4-二硝基苯（DNFB）是修饰蛋白和多肽N端氨基酸的试剂。DNFB通常也称为桑格（Sanger′s）试剂，以Frederick Sanger的名字命名，他在1945年的一篇经典的论文中报道了使用DNFB对蛋白和多肽的N末端进行特异性衍生的过程。
Application
1-氟-2，4-二硝基苯用于诱发小鼠严重接触性超敏反应，通过体内成像方法，检测基因表达和诱发慢性瘙痒，用作分析搔痒行为的模型。
Biochem/physiol Actions
1-氟-2，4-二硝基苯是一种接触过敏性半抗原，通常用于实验研究接触超敏反应，诱发瘙痒模型和特应性皮炎。肥大细胞激活是DNFB诱发过敏的关键步骤。DNFB和蛋白质N端氨基酸共价连接，可用于桑格（Sanger ）测序。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
327.2 °F
flash_point_c
164 °C
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
危险化学品
此项目有
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D1529-100ML | 04061838255112 |
| D1529-25ML | 04061838255136 |
| D1529-10ML | 04061838255129 |
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