D5156
1,2-Dioctanoyl-sn-glycerol
≥96% (TLC), oil
别名:
(S)-Glycerol 1,2-dioctanoate, 1,2-Dicapryloyl-sn-glycerol, D-α,β-Dicaprylin, DOG
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关于此项目
经验公式（希尔记法）:
C19H36O5
化学文摘社编号:
分子量:
344.49
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
1714754
assay
≥96% (TLC)
form
oil
color
yellow
solubility
DMSO: soluble
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC
Biochem/physiol Actions
Cell-permeable, diacylglycerol (DAG) analog, and activator of protein kinase C (PKC). Shown to possess a lower affinity for the α isoform of PKC than for the other isoforms. Mimics the action of tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA). Inhibits slow (L-type) Ca2+ current in rat heart cells independently of PKC activation and also inhibits the cGMP-gated channel in rod outer segments by a phosphorylation-independent mechanism.
Other Notes
Synthetic 1,2-diglyceride of short chain fatty acid.
Disclaimer
Some isomerization to the 1,3-isomer may occur in storage or in solution.
存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
S E Gordon et al.
Biophysical journal, 69(2), 409-417 (1995-08-01)
The electrical response to light in retinal rods is mediated by cyclic nucleotide-gated, nonselective cation channels in the outer segment plasma membrane. Although cGMP appears to be the primary light-regulated second messenger, cellular levels of other substances, including Ca2+ and
C L Grey et al.
Journal of neuroendocrinology, 23(12), 1273-1287 (2011-09-17)
Ghrelin (GRLN) and its receptor have been identified and characterised in goldfish brain and the pituitary, and recent evidence shows that goldfish (g)GRLN(19) induces both growth hormone (GH) and maturational gonadotrophin (LH) release through an extracellular Ca(2+) -dependent mechanism in
Christian Winter et al.
American journal of physiology. Cell physiology, 301(5), C1251-C1261 (2011-08-13)
Urinary acidification in the collecting duct is mediated by the activity of H(+)-ATPases and is stimulated by various factors including angiotensin II and aldosterone. Classically, aldosterone effects are mediated via the mineralocorticoid receptor. Recently, we demonstrated a nongenomic stimulatory effect