D7408
2′,5′-Dideoxyadenosine
≥95% (HPLC), Adenylyl cyclase inhibitor, solid
别名:
2ʹ,5ʹ-dd-Ado, NSC 95943
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关于此项目
经验公式（希尔记法）:
C10H13N5O2
化学文摘社编号:
分子量:
235.24
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
产品名称
2′,5′-Dideoxyadenosine, ≥95% (HPLC), solid
SMILES string
C[C@H]1O[C@H](C[C@@H]1O)n2cnc3c(N)ncnc23
InChI key
FFHPXOJTVQDVMO-DSYKOEDSSA-N
InChI
1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
assay
≥95% (HPLC)
form
solid
color
white
solubility
DMSO: soluble
storage temp.
−20°C
Quality Level
Gene Information
rat ... Adcy2(81636)
Application
2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC).
Biochem/physiol Actions
Cell-permeable adenylyl cyclase inhibitor. IC50 = 2.7 μM in detergent-dispersed rat brain preparations.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Store at −20 °C after reconstitution.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Fen Hu et al.
Molecular medicine reports, 24(4) (2021-07-31)
Inflammation and oxidative stress have indispensable roles in the development of acute lung injury (ALI). MicroRNA (miRNA/miR)‑351‑5p was initially identified as a myogenesis‑associated miRNA; however, its role in lipopolysaccharide (LPS)‑induced ALI remains unclear. The aim of the present study was
Rula Azzam et al.
AIDS research and human retroviruses, 22(7), 619-629 (2006-07-13)
HIV-1 infection of cells of macrophage lineage impairs a number of effector functions performed by these cells, including phagocytosis of opsonized pathogens. In this study we investigate the effects of HIV-1 on the mechanism of complement (C')-mediated phagocytosis by human
Jorge A Rodriguez et al.
American journal of physiology. Heart and circulatory physiology, 290(1), H30-H36 (2005-09-07)
Vascular smooth muscle cell proliferation and migration play an important role in the pathophysiology of several vascular diseases, including atherosclerosis. Prostaglandins that have been implicated in this process are synthesized by two isoforms of cyclooxygenase (COX), with the expression of
Hisatoshi Sugiura et al.
Journal of cellular physiology, 210(1), 99-110 (2006-09-26)
Prostaglandin E(2) (PGE(2)) has been shown to have a strong cytoprotective effect, inhibiting apoptosis. In the present study, we evaluated whether PGE(2) has a protective effect on cigarette smoke extract (CSE)-induced apoptosis in human lung fibroblasts. Apoptosis was assessed by
Zhixiong Chen et al.
International journal for parasitology, 37(7), 743-761 (2007-02-20)
Trichinella spiralis infection causes hyperexcitability in enteric after-hyperpolarising (AH) sensory neurons that is mimicked by neural, immune or inflammatory mediators known to stimulate adenylyl cyclase (AC)/cyclic 3',5'-adenosine monophosphate (cAMP) signaling. The hypothesis was tested that ongoing modulation and sustained amplification
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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