D8663
1,7-二甲基尿酸
~95% (HPLC)
别名:
1,7-二甲基-2,6,8-三羟基嘌呤
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关于此项目
经验公式（希尔记法）:
C7H8N4O3
化学文摘社编号:
分子量:
196.16
EC Number:
251-706-2
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
219682
MDL number:
assay
~95% (HPLC)
SMILES string
CN1C(=O)NC2=C(N(C)C(=O)N2)C1=O
InChI
1S/C7H8N4O3/c1-10-3-4(8-6(10)13)9-7(14)11(2)5(3)12/h1-2H3,(H,8,13)(H,9,14)
InChI key
NOFNCLGCUJJPKU-UHFFFAOYSA-N
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
K L Rost et al.
Clinical pharmacology and therapeutics, 55(4), 402-411 (1994-04-01)
Omeprazole has previously been shown to induce hepatic cytochrome P4501A2 activity, as evidenced by an accelerated N-3-demethylation in the 13C-[N-3-methyl]-caffeine breath test. In this study we investigated whether the inducing potency of omeprazole can be quantified by the determination of
M Vincent-Viry et al.
Genetic epidemiology, 11(2), 115-129 (1994-01-01)
Human acetylation phenotypes were determined with caffeine (137X) as the test substance, improved by measuring urinary caffeine metabolites with a previously described HPLC method. Caffeine, 5-acetylamino-6-formylamino-3-methyluracil (AFMU), 1-methylxanthine (IX), 1-methyluric acid (IU), 1,7-dimethylxanthine (17X), and 1,7-dimethyluric acid (17U) were quantified.
Frank Haberman et al.
Neuromolecular medicine, 9(4), 315-323 (2007-11-14)
Uric acid is a major antioxidant in the blood of humans that can protect cultured neurons against oxidative and metabolic insults. However, uric acid has a very low solubility which compromises its potential clinical use for neurodegenerative disorders. Here we
M E Campbell et al.
Clinical pharmacology and therapeutics, 42(2), 157-165 (1987-08-01)
Systemic caffeine clearance and urinary metabolite profiles were determined in 15 subjects with diverse exposure histories to cytochrome P-450 inducers (cigarette smoke) and inhibitors (oral contraceptive steroids). A correlation was observed between caffeine clearance and a urinary ratio based on
Blanca Sinués et al.
Basic & clinical pharmacology & toxicology, 102(1), 45-49 (2007-10-12)
A large number of metabolic alterations are increasingly being treated with growth hormone. Despite the fact that growth hormone is known to be the main regulator of several hepatic drug metabolizing enzymes in rodents, few studies deal with the effect
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