D9500
2′-脱氧鸟苷5′-单磷酸 钠盐 水合物
≥99% (HPLC), powder
别名:
5′-脱氧鸟苷酸, dGMP
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关于此项目
经验公式（希尔记法）:
C10H14N5O7P · xNa+ · yH2O
分子量:
347.22 (anhydrous free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
产品名称
2′-脱氧鸟苷5′-单磷酸 钠盐 水合物, ≥99% (HPLC)
Quality Level
assay
≥99% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
O.[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP(O)([O-])=O)O3)C(=O)N1
InChI
1S/C10H14N5O7P.Na.H2O/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20;;/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17);;1H2/q;+1;/p-1/t4-,5+,6+;;/m0../s1
InChI key
UVKXYXSKMTUDML-FVALZTRZSA-M
Application
2′-脱氧鸟苷5′-单磷酸钠盐水合物已被用于：
- 反相高压力液相色谱（HPLC）分析
- 确定脱氧单核苷酸对自发增殖的CaCo-2细胞系的影响
- 确定其刺激免疫细胞生长和功能的能力，并在体外使用流行性感冒病毒抗原作为免疫刺激剂
2′-脱氧鸟苷5′-单磷酸酯（dGMP）用作鸟苷酸激酶（EC 2.7.4.8）的底物，形成dGDP，磷酸化为dGTP后可支持DNA生物合成。dGMP用于研究鸟嘌呤类分子的理化特性。
存储类别
11 - Combustible Solids
wgk
WGK 3
Mahmoud Kandeel et al.
Molecular and biochemical parasitology, 159(2), 130-133 (2008-04-01)
The present work describes cloning, expression, purification, characterization, and mutation of Plasmodium falciparum guanylate kinase (PlasmoDB ID PFI1420w). Amino-acid sequence alignment revealed important differences especially in K42-V51, Y73-A77, and F100-L110, which include residues important for kinase activity, and at helix
Ana-Maria Ruxandra Eftimie et al.
Roumanian archives of microbiology and immunology, 66(1-2), 22-25 (2008-10-22)
Guanylate kinase is a member of the nucleoside monophosphate (NMP) kinase family, a family of enzymes that despite having a low primary structure identity share a similar fold, which consists of three structurally distinct regions termed the CORE, LID, and
Brian G Gentry et al.
Biochemical pharmacology, 81(1), 43-49 (2010-09-18)
Many fraudulent nucleosides including the antivirals acyclovir (ACV) and ganciclovir (GCV) must be metabolized to triphosphates to be active. Cyclopropavir (CPV) is a newer, related guanosine nucleoside analog that is active against human cytomegalovirus (HCMV) in vitro and in vivo.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D9500-500MG | 04061833007044 |
| D9500-1G | 04061826690734 |
| D9500-100MG | 04061833007037 |