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E3256

Edrophonium chloride

Name: Edrophonium chloride
Brand: SIGMA

别名:

Ethyl(m-hydroxyphenyl)dimethylammonium chloride

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₆ClNO

化学文摘社编号:

116-38-1

分子量:

201.69

UNSPSC Code:

12352200

PubChem Substance ID:

24278414

EC Number:

204-138-4

MDL number:

MFCD00055064

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SMILES string

[Cl-].CC[N+](C)(C)c1cccc(O)c1

InChI

1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H

InChI key

BXKDSDJJOVIHMX-UHFFFAOYSA-N

Gene Information

human ... ACHE(43)

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Biochem/physiol Actions

Acetycholinesterase inhibitor

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue.

Mathilde M Triquigneaux et al.

The Biochemical journal, 448(1), 83-91 (2012-08-15)

The principal role of AChE (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. The active site of AChE is near the bottom of a long and narrow gorge lined with aromatic residues.

Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension.

Yehonatan Sharabi et al.

Movement disorders : official journal of the Movement Disorder Society, 23(12), 1725-1732 (2008-07-29)

Patients with Parkinson's disease (PD) often have manifestations of autonomic failure. About 40% have neurogenic orthostatic hypotension (NOH), and among PD+NOH patients virtually all have evidence of cardiac sympathetic denervation; however, whether PD+NOH entails extra-cardiac noradrenergic denervation has been less

Myasthenia gravis in an adolescent patient presenting to the pediatric emergency department.

James Rook et al.

Pediatric emergency care, 26(5), 374-375 (2010-05-11)

Myasthenia gravis is a rare, chronic, autoimmune disorder characterized by postsynaptic dysfunction at the neuromuscular junction. The disease affects more females than males. We describe the case of a 17-year-old female adolescent with recurrent episodes of dysarthria and dysphagia and

Pseudo-internuclear ophthalmoplegia as a sign of overlapping myasthenia gravis in a patient with 'intractable' hypothyroidism.

Yuu Yamazaki et al.

Internal medicine (Tokyo, Japan), 49(1), 69-72 (2010-01-05)

We describe a 52-year-old man with a history of increasing fatigability and gait disturbances that were first attributed to hypothyroidism. On examination, he had bilateral pseudo-internuclear ophthalmoplegia with weakness of adduction and abducting nystagmus. Convergence was also impaired and he

Racial differences in myasthenia gravis in Alabama.

Shin J Oh et al.

Muscle & nerve, 39(3), 328-332 (2009-01-08)

Demographic, clinical, and laboratory features were compared in 235 white and African-American (AA) patients with myasthenia gravis (MG) at the University of Alabama at Birmingham Neuromuscular Disease Clinic from May 2003 to January 2008. Seventy nine percent of patients were

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