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Merck
CN

E9750

雌素酮

≥99% (HPLC), powder, estrogen receptor agonist

别名:

3-羟基雌甾-1,3,5(10)-三烯-17-酮, 雌(三烯酚)酮, 雌酮

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关于此项目

经验公式（希尔记法）:
C18H22O2
化学文摘社编号:
53-16-7
分子量:
270.37
NACRES:
NA.77
PubChem Substance ID:
24278427
UNSPSC Code:
51111800
EC Number:
200-164-5
MDL number:
MFCD00003620
Beilstein/REAXYS Number:
1915077
Assay:
≥99%
Form:
powder
Quality level:
200

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产品名称

雌素酮, ≥99%

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥99%

form

powder

mp

258-260 °C (lit.)

solubility

dioxane: 50 mg/mL, clear, colorless to very faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O

InChI

1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

InChI key

DNXHEGUUPJUMQT-CBZIJGRNSA-N

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Esr1(24890)

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相关类别

General description

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

Application

Estrone has been used:
  • as medium supplement for hormone based degranulation studies of natural killer cells
  • as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
  • as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

Biochem/physiol Actions

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF3106V
WXBF4601V
WXBF1727V
BCCJ9107
BCCG0660

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Hormone replacement with estradiol: conventional oral doses result in excessive exposure to estrone
Friel PN, et al.
Alternative Medicine Review, 10(1), 36-42 (2005)
Estrone-a partial estradiol antagonist in the normal breast
Lundstrom E, et al.
Gynecological Endocrinology, 31(9), 747-749 (2015)
Pharmacology of estrogens and progestogens: influence of different routes of administration
Kuhl H
Climacteric : The Journal of the International Menopause Society, 8(1), 3-63 (2005)
Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids
Lopes-Coelho F, et al.
Molecular and cellular endocrinology, 462(9), 93-106 (2018)
Creation of a new portable biosensor for water toxicity determination
Eltzov E, et al.
Sensors and Actuators B, Chemical, 221(9), 1044-1054 (2015)
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商品

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

全球贸易项目编号

货号GTIN
E9750-1G04061835556779
E9750-25G04061833609170
E9750-500MG04061833609187
E9750-5G04061833609194

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