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Merck
CN

G9891

β-甘油磷酸盐 二钠盐 水合物

powder, BioReagent, suitable for cell culture

别名:

BGP, 甘油2-磷酸酯 二钠盐 水合物

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关于此项目

线性分子式:
(HOCH2)2CHOP(O)(ONa)2 · xH2O
化学文摘社编号:
分子量:
216.04 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
212-464-3
MDL number:
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product line

BioReagent

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.20% α-isomer

mp

102-104 °C (lit.)

SMILES string

O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O

InChI

1S/C3H9O6P.2Na.H2O/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;;1H2/q;2*+1;/p-2

InChI key

ROPZSVKNEIIIDE-UHFFFAOYSA-L

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Application

β-甘油磷酸盐是激酶反应缓冲液中丝氨酸-苏氨酸磷酸酶的一种经典抑制剂。BGP通常与其他磷酸酶/蛋白酶抑制剂组合,以实现广谱抑制。它可用作有机磷酸盐供体,并且已用于使间充质干细胞分化为成骨细胞型细胞的培养基。BGP也用于缓冲乳酸菌的M17培养基,以进行重组蛋白表达。
对嵌入天然胶原/壳聚糖凝胶(用于组织工程)中的骨髓衍生干细胞进行诱导分化。
Glycero-2-phosphate is a component of dexamethasone based hormone cocktail used to induce mesechymal stem cell (MSC) differentiation into osteoblasts.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Wen-Ning Xu et al.
Frontiers in endocrinology, 10, 922-922 (2020-02-13)
Long-term and high dose glucocorticoid treatment can cause decreased viability and function of osteoblasts, which leads to osteoporosis and osteonecrosis. In this study, we investigated the role and mechanism of action of HIF-1α in glucocorticoid-induced osteogenic inhibition in MC3T3-E1 cells.
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(5), 775-785 (2014-11-20)
Amelotin (AMTN) is a recently discovered protein that is specifically expressed during the maturation stage of dental enamel formation. It is localized at the interface between the enamel surface and the apical surface of ameloblasts. AMTN knock-out mice have hypomineralized

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