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H2775

DL - 苏式 -β-羟基天冬氨酸

Name: <SC>DL </SC>-<I> 苏式 </I>-β-羟基天冬氨酸
Brand: SIGMA

别名:

苏式 -2-氨基-3-羟基琥珀酸

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关于此项目

经验公式（希尔记法）:

C₄H₇NO₅

化学文摘社编号:

4294-45-5

分子量:

149.10

PubChem Substance ID:

24278465

eCl@ss:

32160406

UNSPSC Code:

12352106

NACRES:

NA.32

EC Number:

224-299-4

MDL number:

MFCD00036749

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Quality Level

200

storage temp.

−20°C

SMILES string

N[C@H]([C@@H](O)C(O)=O)C(O)=O

InChI

1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m1/s1

InChI key

YYLQUHNPNCGKJQ-JCYAYHJZSA-N

Gene Information

human ... GLUL(2752)
mouse ... GLUL(14645)

General description

DL -苏式-β-羟基天冬氨酸 (THA) 是一种谷氨酸摄取抑制剂。

Application

DL-苏氨酸-β-在插管 sprague dawley 大鼠中使用羟基天冬氨酸 (THA) 阻断谷氨酸盐转运。

flash_point_f

Not applicable

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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AMPA receptor-mediated slow neuronal death in the rat spinal cord induced by long-term blockade of glutamate transporters with THA.

A Hirata et al.

Brain research, 771(1), 37-44 (1998-02-12)

Excitotoxicity secondary to the loss of glutamate transporters (GluT) has been proposed as a possible pathogenetic mechanism for neuronal degeneration in amyotrophic lateral sclerosis. We therefore investigated whether prolonged in vivo pharmacologic inhibition of GluT would result in neuronal damage

A practical synthesis of N α-Fmoc protected L-threo-β-hydroxyaspartic acid derivatives for coupling via α- or β-carboxylic group.

Nina Bionda et al.

Amino acids, 42(1), 285-293 (2010-11-18)

A simple and practical general synthetic protocol towards orthogonally protected tHyAsp derivatives fully compatible with Fmoc solid-phase peptide synthetic methodology is reported. Our approach includes enantioresolution of commercially available D: ,L: -tHyAsp racemic mixture by co-crystallization with L: -Lys, followed

Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural study.

Ewa Nagańska et al.

Folia neuropathologica, 48(1), 35-44 (2010-04-13)

Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body including nervous system. For last years its role as cytokine involved in many physiological processes out of the bone marrow has been suggested. Moreover, it plays a

Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions.

Tatiana Borisova et al.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 14(1), P81-P82 (2008-04-01)

Activity of high-affinity glutamate transporters was altered in brain nerve terminals under artificial gravity conditions. Blood platelets contain glutamate transporters and are able to uptake glutamate. The goal of the research was to analyze comparatively L-[14C]glutamate transport in neuronal and

Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons.

Jixu Yu et al.

Brain research, 1257, 102-107 (2009-01-13)

Threohydroxyaspartate (THA)-induced glutamate excitotoxicity in organotypic culture of rat spinal cord is a well-known model of motor neuron degeneration. THA causes accumulation of synaptic glutamate and over stimulation of the postsynaptic receptor by inhibiting glutamate uptake. This model has also

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全球贸易项目编号

货号	GTIN
H2775-50MG	04061833007402
H2775-250MG	04061833007396

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