Anti-FAM120A antibody produced in rabbit

FAM120A (Family with sequence similarity 120A) is a novel RNA-binding protein located to chromosome 9q22.31. It is expressed in the Pura-containing mRNA-protein complex in the brain.

Constitutive coactivator of PPAR-γ-like protein 1 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

FAM120A (Family with sequence similarity 120A), a scaffold protein, acts as signaling molecule in the activation of FAK (Focal Adhesion Kinase) and phosphatidylinositol 3-kinase (PI3-kinase) Pathways. During oxidative stress, FAM120A mainly prevents cells to enter apoptosis by activating SFKs (Src family kinases) in response to oxidative stress. In association with kinesins and motor proteins, FAM120A helps in transport of cargo movement along microtubules.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST75171

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