HPA034669
抗-LBH 兔抗
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Lbh Antibody, Lbh Antibody - Anti-LBH antibody produced in rabbit, Anti-limb bud and heart development homolog (mouse)
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:200-1:500
immunogen sequence
PDYLRSAKMTEVMMNTQPMEEIGLSPRKDGLSYQIFPDPSDFDRCCKLKDRLPSIVVEPTEGEVESGELRWPPEEFLVQEDEQDNCEETAKE
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LBH(81606)
General description
The limb-bud and heart (LBH) gene is mapped to human chromosome 2p23.1. It is mostly expressed in embryonic tissues. LBH is also found in spleen, brain, kidney, gut and peripheral nervous system.
Immunogen
limb bud and heart development homolog (mouse) recombinant protein epitope signature tag (PrEST)
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
Biochem/physiol Actions
Limb-bud and heart (LBH) is a transcription cofactor participating in embryogenesis. It mediates the development of limbs and heart in vertebrates. LBH is might be associated with breast cancer via the WNT signaling pathway. It is also known to be involved in cardiac and skeletal abnormalities.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Other Notes
Corresponding Antigen APREST79257
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
低风险生物材料
常规特殊物品
常规特殊物品
此项目有
Huizhan Liu et al.
Journal of cell science, 134(7) (2021-03-07)
Hearing loss affects ∼10% of adults worldwide. Most sensorineural hearing loss is caused by the progressive loss of mechanosensitive hair cells (HCs) in the cochlea. The molecular mechanisms underlying HC maintenance and loss remain poorly understood. LBH, a transcription co-factor
Elevated limb-bud and heart development (LBH) expression indicates poor prognosis and promotes gastric cancer cell proliferation and invasion via upregulating Integrin/FAK/Akt pathway
Yu R, et al.
PeerJ, 7(11), e6885-e6885 (2019)
Yi Li et al.
PloS one, 11(3), e0151291-e0151291 (2016-03-15)
Regulation of gene expression is essential to determining the functional complexity and morphological diversity seen among different cells. Transcriptional regulation is a crucial step in gene expression regulation because the genetic information is directly read from DNA by sequence-specific transcription
Limb-Bud and heart attenuates growth and invasion of human lung adenocarcinoma cells and predicts survival outcome
Deng M, et al.
Cellular Physiology and Biochemistry, 47(1), 223-234 (2018)
LBH gene transcription regulation by the interplay of an enhancer risk allele and DNA methylation in rheumatoid arthritis
Hammaker D, et al.
Arthritis and Rheumatism, 68(11), 2637-2645 (2016)
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