Anti-NEK10 antibody produced in rabbit

The gene NEK10 (NIMA related kinase 10) is mapped to human chromosome 3p24. The encoded protein belongs to the NEK kinase family of proteins. NEK10 is a serine threonine kinase. The protein has armadillo repeats, coiled coil domains, a kinase domain and a PEST (proline (P), glutamic acid (E), serine (S), and threonine (T)) sequence. NEK10 mRNA is present in the lung, spleen and mammary glands.

NIMA (never in mitosis gene a)- related kinase 10 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

NEK10 (NIMA related kinase 10) regulates G2/M checkpoint after ultraviolet irradiation. It positively regulates ERK1/2 (extracellular signal-regulated kinase) signaling. Genome-wide association study has shown association between NEK10 and breast cancer. Mutations in NEK10 gene have been reported in lung cancer cell lines.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Corresponding Antigen APREST71470

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