I2778
IL-1α human
≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor
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关于此项目
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
lyophilized powder
Mol wt:
~17 kDa
产品名称
白介素1α 人, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
quality
endotoxin tested
mol wt
~17 kDa
packaging
pkg of 2 and 10 μg
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... IL1A(3552)
General description
Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.
Application
Interleukin-1α (IL-1α) has been used:
- to study its effects on human colorectal adenocarcinoma cells
- to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
- to pre-stimulate human THP-1 monocytes
Biochem/physiol Actions
Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.
Physical form
Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.
Analysis Note
The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
flash_point_f
No data available
flash_point_c
No data available
法规信息
常规特殊物品
低风险生物材料
此项目有
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Nelson C Di Paolo et al.
Nature immunology, 17(8), 906-913 (2016-07-21)
Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection and ultimately involves the recruitment and retention of cells of hematopoietic origin, which arrive at the affected sites to resolve damage and initiate repair. Interleukin 1α (IL-1α)
Peleg Rider et al.
Seminars in immunology, 25(6), 430-438 (2013-11-05)
Although the IL-1α molecule has long been recognized, information about its distinct role in various diseases is limited, since most clinical studies have focused on the role of IL-1β. Despite triggering the same IL-1 receptor as does IL-1β, there is
Association of interleukin1 beta, interleukin1 receptor antagonist, interleukin 6 and angiotensin II receptor type I gene polymorphisms with end stage renal disease: A meta-analysis
Divya M, et al.
Gene Reports, 100856-100856 (2020)
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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