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L6524

[D-pGlu1, D-Phe2, D-Trp3,6]-LH-RH

≥97% (HPLC)

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关于此项目

经验公式（希尔记法）:
C67H84N16O13
化学文摘社编号:
68059-94-9
分子量:
1321.48
UNSPSC Code:
12352200
MDL number:
MFCD00076582
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assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H](Cc6ccccc6)NC(=O)[C@H]7CCC(=O)N7)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N8CCC[C@H]8C(=O)NCC(N)=O

InChI

1S/C67H84N16O13/c1-37(2)28-49(59(89)76-48(18-10-26-71-67(69)70)66(96)83-27-11-19-55(83)65(95)74-35-56(68)86)77-62(92)52(31-40-33-72-45-16-8-6-14-43(40)45)80-61(91)51(30-39-20-22-42(85)23-21-39)79-64(94)54(36-84)82-63(93)53(32-41-34-73-46-17-9-7-15-44(41)46)81-60(90)50(29-38-12-4-3-5-13-38)78-58(88)47-24-25-57(87)75-47/h3-9,12-17,20-23,33-34,37,47-55,72-73,84-85H,10-11,18-19,24-32,35-36H2,1-2H3,(H2,68,86)(H,74,95)(H,75,87)(H,76,89)(H,77,92)(H,78,88)(H,79,94)(H,80,91)(H,81,90)(H,82,93)(H4,69,70,71)/t47-,48+,49+,50-,51+,52-,53-,54+,55+/m1/s1

InChI key

NYWIVATZZKIKCF-FKDXDCHSSA-N

Biochem/physiol Actions

Substance P antagonist; inhibits spinal cord vasomotor responses

Other Notes

Similar to L 2636, but produced by Sigma.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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分析证书(COA)

Lot/Batch Number

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F Ma et al.
Biochemical and biophysical research communications, 130(3), 1201-1208 (1985-08-15)
A 2-min addition of LHRH to [3H]inositol-prelabeled rat granulosa cells in primary culture evoked significant increases in the accumulation of [3H]inositol phosphates, i.e. radiolabeled inositol monophosphate (IP), inositol diphosphate (IP2), and inositol triphosphate (IP3) levels increased to 210, 590 and
Role of lipids in gonadotropin releasing hormone agonists and antagonist binding to rat pituitary.
E Hazum et al.
Biochemical and biophysical research communications, 105(1), 8-13 (1982-03-15)
T J Cicero et al.
Life sciences, 42(18), 1725-1732 (1988-01-01)
It has been previously reported that the excitatory amino acid, N-methyl-D-aspartic acid (NMDA), elicits prompt increases in serum luteinizing hormone (LH) levels in young male rats. The present studies were carried out to determine whether the effects of NMDA on
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