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L9761

[D-Trp⁶]-LH-RH

Name: [<SC>D</SC>-Trp<SUP>6</SUP>]-LH-RH
Brand: SIGMA

≥97% (HPLC), powder

别名:

[D-Trp⁶]-Luteinizing hormone releasing hormone

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关于此项目

经验公式（希尔记法）:

C₆₄H₈₂N₁₈O₁₃

化学文摘社编号:

57773-63-4

分子量:

1311.45

NACRES:

NA.32

PubChem Substance ID:

329817674

UNSPSC Code:

12352209

MDL number:

MFCD00167541

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Quality Level

200

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01148, P30968

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](Cc6c[nH]cn6)NC(=O)[C@@H]7CCC(=O)N7)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N8CCC[C@H]8C(=O)NCC(N)=O

InChI

1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1

InChI key

VXKHXGOKWPXYNA-PGBVPBMZSA-N

Gene Information

human ... GNRH1(2796), GNRHR(2798)

Application

[D-Trp6]-LH-RH (luteinizing hormone releasing hormone) has been used to study whether the (M^. – X) region in electron capture dissociation provides information on amino acid composition of polypeptides. It is also used to study the effect of LH-RH on the production of progesterone (P), estradiol (E2) or human chorionic gonadotropin (hCG) by JEG-3 choriocarcinoma cells.

Biochem/physiol Actions

Potent LH-RH agonist with enhanced biological activity due to its slower rate of degradation. Like [D-Lys⁶]-LH-RH, the D-Trp⁶ analog has been shown to be effective against cancers expressing the LH-RH receptor. However, unlike the D-Lys⁶ analog, it is generally used in the unconjugated form.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS08

signalword

Danger

hcodes

H360

pcodes

P201 - P308 + P313

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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Litter size response to oestrous induction with deslorelin (Ovuplant®) in dogs.

T Wolf et al.

Reproduction in domestic animals = Zuchthygiene, 47 Suppl 6, 387-388 (2013-01-04)

Four German Shorthair Pointer bitches each produced from two to five (total of 14) purebred litters in response to natural matings to either natural oestrus (n = 8) or oestrus induced by Ovuplant(®), a sustained-release implant containing 2.1 mg deslorelin

Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation.

Colette Meyer et al.

Endocrine-related cancer, 20(1), 123-136 (2012-12-04)

GNRH significantly inhibits proliferation of a proportion of cancer cell lines by activating GNRH receptor (GNRHR)-G protein signaling. Therefore, manipulation of GNRHR signaling may have an under-utilized role in treating certain breast and ovarian cancers. However, the precise signaling pathways

Treatment of queens in estrus and after estrus with a GnRH-agonist implant containing 4.7 mg deslorelin; hormonal response, duration of efficacy, and reversibility.

Sandra Goericke-Pesch et al.

Theriogenology, 79(4), 640-646 (2012-12-26)

Although slow release GnRH-agonist implants have been shown to effectively suppress the estrous cycle in queens, there are still several remaining questions about their use: if the probability and frequency of estrus induction because of initial stimulation is dependent on

Results of GnRH agonist implants in oestrous induction and oestrous suppression in bitches and queens.

C Maenhoudt et al.

Reproduction in domestic animals = Zuchthygiene, 47 Suppl 6, 393-397 (2013-01-04)

Over the last 10-15 years, long-acting GnRH agonists have become widely available. In the field of small animal reproduction, most recent studies have focused on the use of two compounds developed under the form of subcutaneous implants: azagly-nafarelin and deslorelin.

Can the (M??X) Region in Electron Capture Dissociation Provide Reliable Information on Amino Acid Composition of Polypeptides?

Haselmann K F, et al.

Eur. J. Mass Spectrom., 8(6), 461-469 (2002)

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全球贸易项目编号

货号	GTIN
L9761-5MG	04061833966969
L9761-1MG	04061833966952

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