M2449
MB-3
≥95% (HPLC), Gcn5 HAT inhibitor, powder
别名:
γ-丁内酯, 丁内酯3, (2R,3S)-rel-4-亚甲基-5-氧代-2-丙基四氢呋喃-3-羧酸
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关于此项目
经验公式（希尔记法）:
C9H12O4
分子量:
184.19
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
MB-3, ≥95% (HPLC)
Quality Level
assay
≥95% (HPLC)
form
powder
color
white to off-white
solubility
H2O: ≥10 mg/mL, DMSO: ≥20 mg/mL
storage temp.
−20°C
SMILES string
CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
InChI
1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
InChI key
SRQUTZJZABSZRQ-RQJHMYQMSA-N
Application
MB-3已被用作通用控制蛋白5 (GCN5)抑制剂：
- 研究其对核纤层蛋白A/C相关pY19-Cav-2-介导组蛋白H3乙酰化的影响
- 分析其对拟南芥幼苗生长的影响
- 研究其对颅面软骨细胞成熟的影响
Biochem/physiol Actions
MB-3 是一种 Gcn5 HAT（组蛋白乙酰转移酶）抑制剂；具有抗炎、抗癌作用。
MB-3可以修饰小鼠胚胎干细胞和酵母的基因表达。它通过与GCN5中的乙酰辅酶CoA口袋结合来抑制通用控制蛋白5(GCN5)的乙酰转移酶活性。
Features and Benefits
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
Hong-Bin Cai et al.
Journal of Alzheimer's disease : JAD, 77(1), 75-84 (2020-04-21)
The connection between diabetes and Alzheimer's disease (AD) is not fully determined. Hyperphosphorylation of tau protein is mediated by binding and stabilization of truncated p25 with cyclin-dependent kinase-5 (CDK5) in AD. We recently showed that diabetes-associated hyperglycemia increased the CDK5
Naomi Moris et al.
Stem cells (Dayton, Ohio), 36(12), 1828-1838 (2018-10-03)
Cell fate transitions in mammalian stem cell systems have often been associated with transcriptional heterogeneity; however, existing data have failed to establish a functional or mechanistic link between the two phenomena. Experiments in unicellular organisms support the notion that transcriptional
Anissa Guillemin et al.
PloS one, 14(11), e0225166-e0225166 (2019-11-22)
To better understand the mechanisms behind cells decision-making to differentiate, we assessed the influence of stochastic gene expression (SGE) modulation on the erythroid differentiation process. It has been suggested that stochastic gene expression has a role in cell fate decision-making
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M2449-25MG | 04061832632216 |
| M2449-5MG | 04061832632223 |