N0258
N-亚硝基二乙胺
ISOPAC®
别名:
二乙基亚硝胺
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
线性分子式:
(C2H5)2NNO
化学文摘社编号:
分子量:
102.14
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-226-1
Beilstein/REAXYS Number:
1744991
MDL number:
Form:
liquid
Quality level:
Application
N-亚硝基二乙胺（NDEA）已被用作肝致癌物/DNA损伤剂。它已被用作气液色谱的校准标准品。
Biochem/physiol Actions
N-亚硝基二乙胺（NDEA）是一种有效的肝癌性二烷基亚硝胺。它主要存在于烟草烟雾、水、切达干酪、腌制油炸食品和许多酒精饮料中。NDEA与DNA修复/复制相关的核酶的变化相关。它会导致所有动物物种中的多种肿瘤。其主要靶器官是鼻腔、气管、肺、食道和肝脏。
Packaging
包装于100mL带有硅/PTFE胶垫和铝质撕裂密封的血清瓶中。
Preparation Note
将内容物溶解在100mL溶剂中，可得到1％的溶液。
Legal Information
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
通过注入任何相容的溶剂可在不暴露内容物的情况下制备任何所需强度的溶液。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark.
Singh BN
Chemico-Biological Interactions, 181, 20-20 (2009)
Chemopreventive effect of hydroethanolic extract of Euphorbia neriifolia leaves against DENA-induced renal carcinogenesis in mice.
Pracheta P
Asian Pacific Journal of Cancer Prevention, 12, 677-677 (2011)
Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine.
Yuan F
Proteomics, 13, 389-389 (2013)
The detection of DNA adducts (risk factors for DNA damage). A method for genomic DNA, the results and some effects of nutritional intervention.
Howard JM
Journal of Nutritional & Environmental Medicine, 12, 19-31 (2002)
Yewei Liu et al.
International journal of cancer, 143(7), 1817-1828 (2018-05-01)
To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation
商品
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N0258-1G | 04061834092803 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持