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N0756

N-亚硝基二乙胺

Name: N-亚硝基二乙胺
Brand: SIGMA

liquid, nitrosamine

别名:

二乙基亚硝胺

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关于此项目

线性分子式:

(C₂H₅)₂NNO

化学文摘社编号:

55-18-5

分子量:

102.14

NACRES:

NA.77

PubChem Substance ID:

24897440

UNSPSC Code:

12352116

EC Number:

200-226-1

MDL number:

MFCD00013890

Beilstein/REAXYS Number:

1744991

Form:

liquid

Quality level:

100

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产品名称

N-亚硝基二乙胺, liquid

form

liquid

Quality Level

100

color

yellow

bp

177 °C (lit.)

density

0.95 g/mL (lit.)

SMILES string

CCN(CC)N=O

InChI

1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

InChI key

WBNQDOYYEUMPFS-UHFFFAOYSA-N

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General description

N-亚硝基二乙胺属于亚硝胺类含氮消毒副产物。用氯消毒的水处理设备中也能产生这种副产物。

Application

N-亚硝基二乙胺已用于诱发大鼠和小鼠的肝细胞癌发生。

Biochem/physiol Actions

N-亚硝基二乙胺(NDMA)对于所有受试动物物种都是致癌物。主要靶器官是鼻腔、气管、肺、食道和肝脏。NDMA通过作用于细胞色素P450系统而导致致癌物甲基重氮离子的产生。但假单胞菌等微生物可将NDMA代谢为N-硝基甲胺(NTMA)和甲醛。

Packaging

批量包装

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H350,H412

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

flash_point_c

No data available

pcodes

P202 - P264 - P273 - P280 - P301 + P310 - P405

flash_point_f

No data available

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Occurrence and control of N-nitrosodimethylamine in water engineering systems

Bian Y, et al.

Environmental Engineering Research, 24(1), 1-16 (2018)

Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development

Sarris ME, et al.

Cancer Cell, 29(3), 354-366 (2016)

Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance.

Jun Ho Lee et al.

EBioMedicine, 58, 102926-102926 (2020-08-03)

High recurrence and chemoresistance drive the high mortality in hepatocellular carcinoma (HCC). Although cancer stem cells are considered to be the source of recurrent and chemoresistant tumors, they remain poorly defined in HCC. Tonicity-responsive enhancer binding protein (TonEBP) is elevated

Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis

Choiniere J, et al.

Liver research, 2(2), 100-107 (2018)

Biotransformation of N-nitrosodimethylamine by Pseudomonas mendocina KR1.

Diane Fournier et al.

Applied and environmental microbiology, 72(10), 6693-6698 (2006-09-05)

N-Nitrosodimethylamine (NDMA) is a potent carcinogen and an emerging contaminant in groundwater and drinking water. The metabolism of NDMA in mammalian cells has been widely studied, but little information is available concerning the microbial transformation of this compound. The objective

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全球贸易项目编号

货号	GTIN
N0756-10ML	04061834093008
N0756-25ML	04061834093015

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