drug control
USDEA Schedule II; Home Office Schedule 2; regulated under CDSA - not available from Sigma-Aldrich Canada
General description
Norcocaine is a hepatotoxicant and a metabolite of cocaine. It is synthesized in the liver due to microsomal mixed function oxidases.
Biochem/physiol Actions
可卡因的次要代谢物。
具有生物活性。
具有生物活性。
signalword
Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 1B - Skin Sens. 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Cocaine: Pharamacology, Physiology, and Clinical Strategies (1991)
B W LeDuc et al.
Toxicology and applied pharmacology, 125(2), 322-332 (1994-04-01)
Cocaine (COC) causes liver damage in several species, including man. Chicken embryo hepatocyte cultures were evaluated as a model system to investigate the mechanism of cocaine-mediated hepatotoxicity. Parameters used to assess toxicity were: (1) release of lactate dehydrogenase (LDH); (2)
Handbook of Substance Abuse: Neurobehavioral Pharmacology (1998)