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Merck
CN

N5023

去甲二氢愈创木酸

≥90% (HPLC), from Larrea divaricata (creosote bush)

别名:

1,4-双(3,4-二羟苯基)-2,3-二甲基丁烷, 4,4′-(2,3-二甲基四亚甲基)二邻苯二酚, NDGA, 马索罗酚

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关于此项目

线性分子式:
[-CH(CH3)CH2C6H3-1,2-(OH)2]2
化学文摘社编号:
分子量:
302.36
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
207-903-0
Beilstein/REAXYS Number:
2056826
MDL number:
Assay:
≥90% (HPLC)
Form:
crystalline
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biological source

Larrea divaricata (creosote bush)

assay

≥90% (HPLC)

form

crystalline

mp

184-186 °C (lit.)

solubility

ethanol: 50 mg/mL, clear to slightly hazy

SMILES string

CC(Cc1ccc(O)c(O)c1)C(C)Cc2ccc(O)c(O)c2

InChI

1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3

InChI key

HCZKYJDFEPMADG-UHFFFAOYSA-N

Gene Information

Biochem/physiol Actions

脂氧合酶抑制剂;含多酚的邻二羟基(儿茶酚)结构。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Silvia Arteaga et al.
Journal of ethnopharmacology, 98(3), 231-239 (2005-04-09)
Although controversial, Creosote bush, Larrea tridentata (Sesse and Moc. ex DC) Coville, is used to treat a variety of illnesses including infertility, rheumatism, arthritis, diabetes, gallbladder and kidney stones, pain and inflammation. Recently, it has been used as a nutritional
Victor Kenyon et al.
Journal of medicinal chemistry, 54(15), 5485-5497 (2011-07-12)
We report the discovery of novel small molecule inhibitors of platelet-type 12-human lipoxygenase, which display nanomolar activity against the purified enzyme, using a quantitative high-throughput screen (qHTS) on a library of 153607 compounds. These compounds also exhibit excellent specificity, >50-fold
Lorena Palacio et al.
Plant science : an international journal of experimental plant biology, 193-194, 1-7 (2012-07-17)
The lignan nordihydroguaiaretic acid (NDGA) and its derivatives existing in Larrea divaricata species show a wide range of pharmacological activities which makes this genus an interesting target to consider the plant in vitro cultivation systems as a feasible alternative source



全球贸易项目编号

货号GTIN
N5023-5G04061832785738
N5023-500MG04061832785721
N5023-1G04061826683743