Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody produced in goat

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. Signaling of NGF through NGFR is also implicated in inflammation and allergic reactions. Expression of NGFR has been associated with favourable prognosis and survival in breast and pancreatic cancers
Anti-Nerve Growth Factor Receptor/TNFRSF16 recognizes human NGF R.

purified, Sf21-derived recombinant human p75 neurotrophin R extracellular domain.

Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

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