N8403
6-Nitroso-1,2-benzopyrone
ADP-ribosyltransferase inhibitor
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C9H5NO3
化学文摘社编号:
分子量:
175.14
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
form
solid
storage temp.
−20°C
SMILES string
O=Nc1ccc2OC(=O)C=Cc2c1
InChI
1S/C9H5NO3/c11-9-4-1-6-5-7(10-12)2-3-8(6)13-9/h1-5H
InChI key
HXTDAUGEZTYMGP-UHFFFAOYSA-N
Application
Binds to the DNA-recognizing domain of ADP-ribosyltransferase and preferentially destabilizes one of the two zinc finger polypeptide complexes. The affected enzyme loses almost all activity, but still binds to DNA.
Binds to the DNA-recognizing domain of ADP-ribosyltransferase and preferentially destabilizes one of the two zinc finger polypeptide complexes. The affected enzyme loses almost all activity, but still binds to DNA.>
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jeremy G Owen et al.
The Biochemical journal, 436(3), 709-717 (2011-04-07)
PPTases (phosphopantetheinyl transferases) are of great interest owing to their essential roles in activating fatty acid, polyketide and non-ribosomal peptide synthetase enzymes for both primary and secondary metabolism, as well as an increasing number of biotechnological applications. However, existing techniques
Maria Koulmanda et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(42), 16242-16247 (2008-10-15)
Invasive insulitis is a destructive T cell-dependent autoimmune process directed against insulin-producing beta cells that is central to the pathogenesis of type 1 diabetes mellitus (T1DM) in humans and the clinically relevant nonobese diabetic (NOD) mouse model. Few therapies have
K G Buki et al.
FEBS letters, 290(1-2), 181-185 (1991-09-23)
6-Nitroso-1,2-benzopyrone, an oxidation product of 6-amino-1,2-benzopyrone, binds to the DNA-recognizing domain of the ADP-ribose transferase protein and preferentially destabilizes Zn2+ from one of the two zinc finger polypeptide complexes present in the intact enzyme, as determined by the loss of