O2750
乳清酸
≥98% (titration), anhydrous
别名:
2,6-二羟基嘧啶-4-羧酸, 6-羧基-2,4-二羟基嘧啶, 尿嘧啶-6-羧酸, 脲嘧啶-6-羧酸
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关于此项目
经验公式（希尔记法）:
C5H4N2O4
化学文摘社编号:
分子量:
156.10
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
200-619-8
Beilstein/REAXYS Number:
383901
MDL number:
Assay:
≥98% (titration)
grade
anhydrous
Quality Level
assay
≥98% (titration)
mp
≥300 °C
SMILES string
OC(=O)C1=CC(=O)NC(=O)N1
InChI
1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
InChI key
PXQPEWDEAKTCGB-UHFFFAOYSA-N
Application
乳清酸（OA）是从头嘧啶生物合成的中间体，可用于研究乳清酸磷酸核糖基转移酶（OPRT）的特异性和动力学，其催化从 5′-磷酸-α-d-核糖 1′-二磷酸（PRPP）到乳清酸（OA）的可逆磷酸核糖转移，形成焦磷酸盐和乳清酸 5′-单磷酸（OMP）。乳清酸用作通过产氨棒杆菌（ATCC 6872）或酿酒酵母等微生物潜在的商业生物生产尿苷 5′-单磷酸（UMP）的原料。乳清酸可用于研究 AMPK/SREBP-1 依赖性细胞信号传导途径,以及研究诱导肝脏脂肪生成的转录调节机制。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Juliana Cheleski et al.
European journal of medicinal chemistry, 45(12), 5899-5909 (2010-10-23)
The enzyme dihydroorotate dehydrogenase (DHODH) has been suggested as a promising target for the design of trypanocidal agents. We report here the discovery of novel inhibitors of Trypanosoma cruzi DHODH identified by a combination of virtual screening and ITC methods.
Thomas D Loan et al.
New biotechnology, 49, 104-111 (2018-10-23)
Nucleoside triphosphates (NTPs) are important synthetic targets with diverse applications in therapeutics and diagnostics. Enzymatic routes to NTPs from simple building blocks are attractive, however the cost and complexity of assembling the requisite mixtures of multiple enzymes hinders application. Here
David Pérez-Pascual et al.
Frontiers in microbiology, 8, 2168-2168 (2017-11-23)
A fascinating characteristic of most members of the genus
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O2750-10G | 04061834227151 |