P0054
Anti-PIP5K3 (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-1-phosphatidylinositol-4-phosphate 5-kinase, Anti-Fab1, Anti-Fyve finger-containing phosphoinositide kinase, Anti-P235, Anti-PIKfyve, Anti-PIP5K, Anti-Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
12
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
packaging
antibody small pack of 25 μL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
western blot: 2-4 μg/mL using HEK-293T cells expressing human PIP5K3.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PIP5K3(200576)
mouse ... Pip5k3(18711)
rat ... Pip5k3(316457)
General description
Phosphatidylinositol-3-phosphate-5-kinase, type 3 (PIP5K3, also known as PIKfyve and FAB1) belongs to a large family of lipid kinases that modify the phosphorylation state of phosphatidylinositol (PtdIns). PIP5K3 has been shown to be localized on early and late endosomes.
Phosphatidylinositol-3-phosphate/phosphatidylinositol-5-kinase, type III (PIP5K3) is a constituent of a trimolecular protein complex. It is a 2089 amino acid protein. The gene encoding it is located on human chromosome 2 and has 41 exons.
Application
Anti-PIP5K3 (N-terminal) antibody produced in rabbit can be used in several immunochemical techniques including immunoblotting.
Biochem/physiol Actions
Anti-PIP5K3 (N-terminal) specifically recognizes human PIP5K3.
Phosphatidylinositol-3-phosphate-5-kinase, type 3 (PIP5K3) enzymatic activity is critical for cell morphology and endocytic membrane homeostasis. PIP5K3 acts as a negative regulator of endosome function or regulating endosome-trans-golgi-network (TGN) trafficking. It negatively regulates exocytosis on neurosecretory cells. PIP5K3 regulates the trafficking of IRAP/GLUT4 vesicles to plasma membrane in adipocytes, suggesting that it may play a pleiotropic role in membrane trafficking, including the exocytic pathway.
Phosphatidylinositol-3-phosphate/phosphatidylinositol-5-kinase, type III (PIP5K3) is involved in the synthesis of phosphatidylinositol 3, 5-bisphosphate. It also possesses a protein kinase activity. PIP5K3 regulates specific signaling pathways as well as membrane trafficking. Mutations in the gene encoding it are associated with fleck corneal dystrophy.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636
Diego Sbissa
American Journal of Physiology. Cell Physiology (2012)
PIKfyve negatively regulates exocytosis in neurosecretory cells
Osborne SL, et al.
The Journal of biological chemistry, 283(5), 2804-2813 (2008)
Localized PtdIns 3, 5-P2 synthesis to regulate early endosome dynamics and fusion
Ikonomov OC, et al.
The American Journal of Physiology, 291(2), C393-C404 (2006)
Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice
Kawasaki T, et al.
The Embo Journal, 36(12), 1707-1718 (2017)
A novel PIKFYVE mutation in fleck corneal dystrophy
Andreas K
Molecular Vision (2011)
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持