P7854
Anti-Presenilin-1 (S182) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-ACNINV3, Anti-AD3, Anti-FAD, Anti-PS-1, Anti-PS1, Anti-S182
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IHC (p), WB
Citations:
12
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human, Xenopus, rat
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using methacarn-fixed, formic acid-treated sections of Alzheimer′s Disease (AD) brain, microarray: suitable, western blot: 1:10,000 using whole cell extract of PC12 rat adrenal pheochromocytoma cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PSEN1(5663)
mouse ... Psen1(19164)
rat ... Psen1(29192)
General description
Presenilin 1& 2 (PS1 and PS2) are highly homologous proteins (approx. 43-52 kD) with eight transmembrane domains. In the brain, PS1 and PS2 are expressed primarily in neurons and localized mainly in cell bodies, axons and dendrites. In non-neuronal cells, PS1 and PS2 are localized to the nuclear membrane, endoplasmic reticulum and Golgi. Presenilin 1 is located on chromosome 14.
Immunogen
synthetic peptide corresponding to the C-terminal of human presenilin-1 (amino acids 450-467 with N-terminally added lysine) conjugated to KLH.
Application
Anti-Presenilin-1 (S182) antibody produced in rabbit has been used in:
- immunostaining
- immunofluorescence detection
- immunohistochemistry
- immunoblotting
Biochem/physiol Actions
Specific for presenilin 1 (not found in presenilin 2) and is identical in mouse, rat, and Xenopus. By immunoblotting, the antibody reacts with presenilin 1 (PS1, S182) and with the PS1 cleavage product.
The biological functions of the presenilin′s are yet unknown, but they are thought to be involved in protein trafficking. Mutations in the presenilin 1 (PS1) gene (>30 known pathogenic mutations) have been found in about half of the early-onset familial Alzheimer′s disease (FAD), while only two pathogenic mutations have been found in PS2.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
法规信息
低风险生物材料
常规特殊物品
此项目有
The presenilins
Tandon A and Fraser P
Genome Biology, 3(11) (2002)
The role of presenilins in Alzheimer?s disease
Thinakaran G
The Journal of Clinical Investigation, 104(10), 1321-1327 (1999)
Evangelos Konstantinidis et al.
Molecular therapy. Nucleic acids, 28, 450-461 (2022-05-05)
Presenilin 1 (PS1) is a central component of γ-secretase, an enzymatic complex involved in the generation of the amyloid-β (Aβ) peptide that deposits as plaques in the Alzheimer's disease (AD) brain. The M146L mutation in the PS1 gene (PSEN1) leads
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria
Area-Gomez E, et al.
The American Journal of Pathology, 175(5), 1810-1816 (2009)
Silvia Di Loreto et al.
Experimental gerontology, 57, 57-65 (2014-05-20)
Although the beneficial responses induced in the central nervous system by early-initiated exercise have been broadly investigated, the effects of a chronic and moderate lately-initiated exercise on biochemical hallmarks of very early brain senescence have not been extensively studied. We
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