P8765
吡咯烷二硫代氨基甲酸铵
~99%
别名:
1-吡咯烷二硫代羧酸 铵盐, APDC, PDC, PDTC, 吡咯烷二硫代氨基甲酸铵
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关于此项目
线性分子式:
C5H9NS2 · NH3
化学文摘社编号:
分子量:
164.29
UNSPSC Code:
12352107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
225-834-4
Beilstein/REAXYS Number:
3730472
MDL number:
biological source
microbial
Quality Level
assay
~99%
form
(powderor powder with lumps)
mp
153-155 °C (lit.)
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
N.SC(=S)N1CCCC1
InChI
1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
InChI key
MDDIUTVUBYEEEM-UHFFFAOYSA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846), RELA(5970)
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General description
吡咯烷二硫代甲酸铵盐是一种核因子κB (NF-κB)抑制剂。它作为一种螯合剂，可以从溶液中预浓缩痕量金属。吡咯烷二硫代甲酸铵盐（PDTC）具有抗氧化性质。它能抑制淋巴细胞、神经元和血管内皮细胞的凋亡。
Application
吡咯烷二硫代甲酸铵盐已被用于：
消除人脑细胞中microRNA-146a启动子荧光素酶报告基因活性
- 抑制人单核细胞中的核因子κB（NF-κB）动员和TNF（肿瘤坏死因子）产生
- 降低大鼠的中性粒细胞活性
- 防止阿霉素（ADR）处理的足细胞的Ca2+内流
消除人脑细胞中microRNA-146a启动子荧光素酶报告基因活性
Biochem/physiol Actions
通过抑制 NOS mRNA 的翻译从而阻止一氧化氮合成酶的诱导；引发大鼠平滑肌细胞中的细胞凋亡并抑制白血病 HL-60 细胞中的细胞凋亡。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Quan Zhou et al.
Oncogene, 39(7), 1414-1428 (2019-10-30)
Gastric cancer (GC) is characterized by extensive local invasion, distant metastasis and poor prognosis. In most cases, GC progression is associated with aberrant expression of cytokines or activation of signaling cascades mediated by tumor-stroma interactions. However, the mechanisms by which
An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
Lukiw WJ, et al.
The Journal of Biological Chemistry, 283(46), 31315-31322 (2008)
Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells
Tsai JC, et al.
The Journal of Biological Chemistry, 271(7), 3667-3670 (1996)
Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production
Ye J, et al.
Experimental Cell Research, 340(2), 315-326 (2016)
Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage
Friedrich V, et al.
Journal of Neuroinflammation, 8(1), 103-103 (2011)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P8765-25G | 04061834401766 |
| P8765-1G | 04061834401759 |
| P8765-100G | 04061835522477 |
| P8765-5G | 04061834401773 |
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