InChI
1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H
SMILES string
Oc1ccc(cc1)C2=CC(=O)c3c(O)c(O)c(O)cc3O2
InChI key
JVXZRQGOGOXCEC-UHFFFAOYSA-N
biological source
Erigeron breviscapus
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
yellow
solubility
DMSO: 1 mg/mL, clear, greenish-yellow
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
Flavonoid that is selectively cytotoxic toward cancer cells. Induces mitochondrial ROS, DNA damage, and metabolic suppression, preferentially in tumor cells. Scutellarein has been shown to have better absorption than scutellarin in Caco-2 monolayer cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xiuhua Hao et al.
Journal of pharmaceutical and biomedical analysis, 38(2), 360-363 (2005-06-01)
A validated HPLC method was developed for the quantification of scutellarin in rat plasma using a liquid-liquid extraction and an ultraviolet detection. Chromatographic separation of scutellarin in plasma was performed on a C18 column, with a mobile phase of acetonitrile-water
Anna Berim et al.
Plant physiology, 160(2), 1052-1069 (2012-08-28)
Polymethoxylated flavonoids occur in a number of plant families, including the Lamiaceae. To date, the metabolic pathways giving rise to the diversity of these compounds have not been studied. Analysis of our expressed sequence tag database for four sweet basil
Nian-Guang Li et al.
Bioorganic & medicinal chemistry, 20(24), 6919-6923 (2012-11-08)
Two series of 8-aminomethylated derivatives were prepared by Mannich reaction of scutellarein (2) with appropriate aliphatic amines, alicyclic amines and formaldehyde. All the compounds were tested for their thrombin inhibition activity through the analyzation of prothrombin time (PT), activated partial
Yongjiang Wu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 934-939 (2011-05-13)
The application of near-infrared (NIR) spectroscopy for in-line monitoring of extraction process of scutellarein from Erigeron breviscapus (vant.) Hand-Mazz was investigated. For NIR measurements, two fiber optic probes designed to transmit NIR radiation through a 2 mm pathlength flow cell
Jian-feng Xing et al.
Acta pharmacologica Sinica, 32(5), 655-663 (2011-04-26)
To study the metabolic and pharmacokinetic profile of scutellarin, an active component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz, and to investigate the mechanisms underlying the low bioavailability of scutellarin though oral or intravenous administration in rats. HPLC method
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