S1450
Anti-Superoxide Dismutase (MnSOD) (DD-17)−Cy3 antibody produced in rabbit
1-2 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-IPO-B, Anti-Indophenoloxidase B, Anti-MNSOD, Anti-Manganese Superoxide Dismutase 2, Anti-Manganese dependent SOD, Anti-Mitochondrial SOD, Anti-SOD2, Anti-Superoxide dismutase 2
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
CY3 conjugate
Clone:
polyclonal
Application:
IF (d)
Citations:
8
biological source
rabbit
conjugate
CY3 conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
packaging
antibody small pack of 25 μL
concentration
1-2 mg/mL
technique(s)
direct immunofluorescence: 2-5 μg/mL using human HeLa, rat NRK and mouse 3T3 cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SOD2(6648)
General description
The SOD2 (superoxide dismutase 2) gene is mapped to human chromosome 6q25.3. The encoded protein functions as a tetramer and is localized to mitochondria.
Immunogen
synthetic peptide corresponding to amino acid residues 183-199 of human superoxide dismutase (MnSOD), conjugated to KLH. The corresponding sequence is conserved in many eukaryotes.
Application
Anti-Superoxide Dismutase (MnSOD) (DD-17)-Cy3 antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
Superoxide dismutase 2 (SOD2) is an antioxidant enzyme and catalyzes the conversion of superoxide to hydrogen peroxide and molecular oxygen. The enzyme offers protection against oxidative damage induced by reactive oxygen species and is also radioprotective. The gene is associated with the metastasis and invasion process of salivary adenoid cystic carcinoma. Manganese SOD is involved in detoxification.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Patrick D Bhola et al.
The Journal of clinical investigation, 126(10), 3827-3836 (2016-09-07)
Upfront resistance to chemotherapy and relapse following remission are critical problems in leukemia that are generally attributed to subpopulations of chemoresistant tumor cells. There are, however, limited means for prospectively identifying these subpopulations, which hinders an understanding of therapeutic resistance.
Substrate-analog binding and electrostatic surfaces of human manganese superoxide dismutase.
Azadmanesh J, et al.
Journal of Structural Biology, 199(1), 68-75 (2017)
SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma.
Chang B, et al.
Scientific Reports, 6, 25918-25918 (2016)
Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue.
Zhang Z, et al.
Oncotarget, 8(5), 7791-7791 (2017)
Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma.
Li S, et al.
Oncotarget, 7(22), 32408-32408 (2016)
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