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S4526

盐霉素

from Streptomyces albus, ≥98% (HPLC), powder, MDRP-1 inhibitor

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关于此项目

经验公式（希尔记法）:
C42H70O11
化学文摘社编号:
53003-10-4
分子量:
751.00
UNSPSC Code:
12352200
PubChem Substance ID:
329824546
NACRES:
NA.77
EC Number:
258-290-1
Assay:
≥98% (HPLC)
Quality level:
200
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产品名称

盐霉素, from Streptomyces albus, ≥98% (HPLC)

biological source

Streptomyces albus

Quality Level

200

assay

≥98% (HPLC)

mp

112.5-113.5 °C (lit.)

antibiotic activity spectrum

neoplastics

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

CC[C@H]([C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]2O[C@@]3(O[C@@]4(CC[C@](C)(O4)[C@H]5CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)C(O)=O

InChI

1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1

InChI key

KQXDHUJYNAXLNZ-XQSDOZFQSA-N

General description

Chemical structure: polyether

Application

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44+CD24- mesenchymal-like subpopulation within breast carcinomas.

Biochem/physiol Actions

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000462909
0000462909
0000141658
0000202393
0000419120

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Gynecologic oncology, 129(3), 598-605 (2013-03-19)
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J S van der Linde-Sipman et al.
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全球贸易项目编号

货号GTIN
S4526-25MG04061836927448
S4526-5MG04061836927462
S4526-50MG04061838446619