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S4760

N-琥珀酰-丙氨酸-丙氨酸-丙氨酸-p-硝基苯胺

Name: N-琥珀酰-丙氨酸-丙氨酸-丙氨酸-<I>p</I>-硝基苯胺
Brand: SIGMA

elastase substrate, chromogenic, ≥98% (HPLC), powder

别名:

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸4-硝基苯胺, N-琥珀酰-三-L-丙氨酸4-硝基苯胺

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₅N₅O₈

化学文摘社编号:

52299-14-6

分子量:

451.43

NACRES:

NA.32

PubChem Substance ID:

24899617

UNSPSC Code:

12352204

EC Number:

257-823-5

MDL number:

MFCD00036774

Beilstein/REAXYS Number:

2928351

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属性

产品名称

N-琥珀酰-丙氨酸-丙氨酸-丙氨酸-p-硝基苯胺, elastase substrate

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

DMF: 25 mg/mL, clear, colorless to light yellow

storage temp.

2-8°C

SMILES string

C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C19H25N5O8/c1-10(20-15(25)8-9-16(26)27)17(28)21-11(2)18(29)22-12(3)19(30)23-13-4-6-14(7-5-13)24(31)32/h4-7,10-12H,8-9H2,1-3H3,(H,20,25)(H,21,28)(H,22,29)(H,23,30)(H,26,27)/t10-,11-,12-/m0/s1

InChI key

GVUGADOWXGKRAE-SRVKXCTJSA-N

说明

General description

N-琥珀酰-Ala-Ala-Ala-对硝基苯胺是糜蛋白酶样丝氨酸蛋白酶、胰弹性蛋白酶和丝氨酸内肽酶的显色底物。

弹性蛋白酶底物。

Application

N-琥珀酰-Ala-Ala-Ala-对硝基苯胺作为底物用于

筛选冻干蚯蚓纤溶酶中弹性蛋白酶的活性
量化羊奶中的弹性蛋白酶的活性
在丝氨酸蛋白酶抑制分析中筛选蜜蜂抑制剂

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

Enzymatic Assay of Elastase (EC 3.4.21.36)

Enzymatic Assay of Elastase (EC 3.4.21.36), a continuous spectrophotometric rate determination.

商品

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Oral fluid elastase as an indicator of periodontal health.

V J Uitto et al.

Journal of clinical periodontology, 23(1), 30-37 (1996-01-01)

The study was designed to find out whether oral elastase activity could be used as a simple biochemical indicator of periodontal health. Both stimulated whole saliva and water rinse samples were collected from subjects with different degrees of adult periodontitis

Elevated Baseline Salivary Protease Activity May Predict the Steadiness of Gingival Inflammation During Periodontal Healing: A 12-Week Follow-Up Study on Adults.

Ulvi Kahraman Gürsoy et al.

Pathogens (Basel, Switzerland), 9(9) (2020-09-19)

Aim was to profile salivary total protease, Porphyromonas gingivalis gingipain, and neutrophil elastase activities in relation to the resolution of periodontal inflammation, salivary macrophage-derived chemokine (MDC), and macrophage inflammatory protein-1α concentrations. Nonsurgical periodontal treatment was performed in 24 periodontitis patients

In Situ and Multisubstrate Detection of Elastase Enzymatic Activity External to Microdialysis Sampling Probes Using LC- ESI-MS

Wang Y, et al.

Analytical Chemistry, 80(6), 2050-2057 (2008)

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全球贸易项目编号

货号	GTIN
S4760-5MG	04061832918518
S4760-500MG	04061836928513
S4760-100MG	04061836928315
S4760-25MG	04061836928353