S5521
Suxibuzone
别名:
4-Butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate (ester)
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关于此项目
经验公式（希尔记法）:
C24H26N2O6
化学文摘社编号:
分子量:
438.47
UNSPSC Code:
12352202
PubChem Substance ID:
EC Number:
248-477-6
MDL number:
form
solid
SMILES string
CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3
InChI
1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)
InChI key
ONWXNHPOAGOMTG-UHFFFAOYSA-N
Biochem/physiol Actions
A prodrug of phenylbutazone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
[The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione(suxibuzone), antiinflammatory drug. I. Plasma levels and urinary excretion after oral administration of suxibuzone (author's transl)].
T Shindo et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 99(12), 1186-1200 (1979-12-01)
[The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione (suxibuzone), antiinflammatory drug. II. The biological fate of suxibuzone (SB) after daily oral administration (author's transl)].
K Taira et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 100(3), 272-279 (1980-03-01)
S Yanagi et al.
Cancer letters, 36(1), 11-18 (1987-07-01)
Among phenylbutazone (PZ) and its related compounds, suxibuzone (SUX) caused the most extensive decrease in pyruvate kinase (PK) activity with lower toxicity. Therefore, we studied the effect of SUX on rat hepatocarcinogenesis to confirm our assumption that an agent which