Anti-Epstein-Barr BGLF4 Kinase (N-term) antibody produced in rabbit

Epstein-Barr BGLF4 plays many key roles by phosphorylating several proteins including the viral DNA processivity factor BMRF1, EBNA1 or EBNA2. It is required for efficient lytic DNA replication and release of nucleocapsids from the nucleus. This protein contributes to the compaction of host cell chromatin in cells undergoing lytic replication, presumably by phosphorylating the host condensin complex and host TOP2A. BGLF4 induces disassembly of the nuclear lamina by phosphorylating with host LMNA, and phosphorylates substrates involved in capsid assembly and DNA packaging. It facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function. This protein phosphorylates the viral immediate-early protein BZLF1.

BGL (1-30)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of Epstein-Barr BGLF4 Kinase.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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