SAB1305652
ANTI-CD11B(N-TERMINAL) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
CD11 antigen-like family member B, CD11B, CR3A, ITGAM, Integrin alpha-M
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
FACS, IHC, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
127179 Da
species reactivity
human
technique(s)
flow cytometry: 1:10-1:50, immunohistochemistry: 1:50-1:100, western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITGAM(3684)
General description
Cluster of differentiation 11b (CD11b), also known as integrin subunit α M (ITGAM), is encoded by the gene mapped to human chromosome 16p11.2. It belongs to the integrin α chain family. CD11b is expressed by a variety of myeloid cell types, such as dendritic cells, macrophages, monocytes and neutrophils.
Biochem/physiol Actions
Cluster of differentiation 11b (CD11b) acts as a receptor for complement component C3 degradation product, iC3b. CD11b interacts with β2 chain (ITGB2) to form a leukocyte integrin (MAC-1 or complement receptor 3 (CR3)), which in turn plays a crucial role in adherence of neutrophils and monocytes to stimulated endothelium. Mutation in the gene increases the risk of susceptibility to systemic lupus erythematosus (SLE) and acute inflammatory demyelinating polyradiculoneuropathy (AIDP).
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
Association of Systemic Lupus Erythematosus with C8orf13?BLK and ITGAM?ITGAX
Geoffrey Hom,et al.
New. J. Chem. (2008)
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Harley JB, et al.
Nature Genetics (2008)
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
Nath SK, et al.
Nature Genetics (2008)
The pathogenic relevance of aM-integrin in Guillain-Barre syndrome.
Acta Neuropathologica (2016)
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