SAB4200334
Anti-phospho-CD3ζ (pTyr142) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-CD247, Anti-CD3H, Anti-CD3Q, Anti-CD3Z, Anti-T cell receptor T3 zeta chain, Anti-T3Z, Anti-TCRK, Anti-Tcrz
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 1-2 μg using lysates of HEK-293T cells co-expressing mCD3ϲ and constitutively active LCK., western blot: 0.5-1 μg/mL using lysates of HEK-293T cells co-expressing mCD3ϲ and constitutively active LCK.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr142)
Quality Level
Gene Information
human ... CD247(919)
mouse ... Cd247(12503)
General description
The TCR-CD3 multimeric complex is composed of TCRαβ, CD3γε and CD3δε and TCR‐ζ homodimer. The CD3γ, CD3δ and CD3ε, each contain one immunoreceptor tyrosine-based activation motif (ITAM), whereas the ζ chain contains three ITAMs.
Immunogen
synthetic phosphopeptide corresponding to residues surrounding Tyr142 of mouse CD3ζ, conjugated to KLH. The corresponding sequence is identical in human CD3ζ.
Application
Anti-phospho-CD3ζ (pTyr142) antibody produced in rabbit has been used in several immunochemical techniques including immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Amongst the TCR subunits, the CD3 ζ chain plays a key role in regulating TCR assembly, transport, and cell surface expression. Down-regulation of TCR ζ chain expression associated with T cell dysfunction was described in various pathologies.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response
Baniyash M.
Nature Reviews: Immunology, 4, 675-687 (2004)
Function of Cd3?-Mediated Signals in T Cell Development
Sommers C. L.
The Journal of Experimental Medicine, 192, 913-913 (2000)
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
Kim K D, et al.
Nature Communications, 8, 1-10 (2017)
Kyun-Do Kim et al.
Nature communications, 8, 15365-15365 (2017-05-16)
Adoptive cell transfer utilizing tumour-targeting cytotoxic T lymphocytes (CTLs) is one of the most effective immunotherapies against haematological malignancies, but significant clinical success has not yet been achieved in solid tumours due in part to the strong immunosuppressive tumour microenvironment.
An architectural perspective on signaling by the pre?, ?? and ?? T cell receptors
Hayes SM, et al.
Immunological Reviews, 191, 28-37 (2003)
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