SAB4200382
Anti-FAM48A /P38IP antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-C13, Anti-C13ORF19, Anti-FP757, Anti-Family with sequence similarity 48, member A, Anti-SPT20, Anti-bA421P11.4, Anti-p38 interacting protein
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~95 kDa
species reactivity
mouse, rat, human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 1-2 μg/mL using monkey COS7 cells, western blot: 1-2 μg/mL using whole extract of human HEK-293T cells, western blot: 2.5-5.0 μg/mL using whole extracts of mouse A20 and rat PC12 cells
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FAM48A(55578)
mouse ... Fam48a(56790)
rat ... Fam48a(361946)
General description
p38-interacting protein (p38IP), also named family with sequence similarity 48, member A (FAM48A) p38IP comprises nuclear localization sequence, two serine rich domains and a PEST domain. It is localized in the nucleus and the cytoplasm. It partially colocalizes with autophagy related protein 9 (Atg9). p38IP is mapped to human chromosome 13q13.3.
Immunogen
synthetic peptide corresponding to an internal region of human FAM48A, conjugated to KLH. The corresponding sequence is identical in mouse, rat, bovine, canine and monkey.
Application
Anti-FAM48A /P38IP antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Anti-FAM48A /P38IP recognizes human and monkey FAM48A /P38IP.
p38-interacting protein (p38IP) binds directly to p38 mitogen activated protein kinase and is required for its activation in vivo. Both p38 and p38IP were found to be necessary for E-cadherin down-regulation during gastrulation. Recently, p38IP was identified as an interacting protein for autophagy-related protein 9 (mAtg9), a transmembrane protein required for autophagy. The interaction of p38IP with mAtg9 is regulated by p38. p38IP is required for starvation-induced mAtg9 trafficking and autophagosome formation.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Childhood Apraxia of Speech (CAS) in two patients with 16p11. 2 microdeletion syndrome
Raca G, et al.
European Journal of Human Genetics, 21(4), 455-459 (2013)
New insights into the function of Atg9
Webber JL and Tooze SA
Febs Letters, 584(7), 1319-1326 (2010)
Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP
Webber JL and Tooze SA
The Embo Journal, 29(1), 27-40 (2010)
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
Zohn IE, et al.
Cell, 125(5), 957-969 (2006)
相关内容
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