SAB4200597
Monoclonal Anti-FMR1 antibody produced in mouse
clone FMR2.5, hybridoma cell culture supernatant
别名:
FMRP, FRAXA, POF, POF1, fragile X mental retardation 1
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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
FMR2.5, monoclonal
Application:
FACS, ICC, IF
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
FMR2.5, monoclonal
form
buffered aqueous solution
mol wt
~71 kDa
species reactivity
rat, human, mouse, hamster
concentration
~1 mg/mL
technique(s)
flow cytometry: 2.0-5.0 μg/test using HeLa cells, immunoblotting: 1.0-2.0 μg/mL using HepG2 total cell extracts., immunocytochemistry: suitable, immunofluorescence: 5-10 μg/mL using HepG2 cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FMR1(2332)
mouse ... Fmr1(14265)
rat ... Fmr1(24948)
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General description
Monoclonal Anti-FMR1 (mouse IgG1 isotype) is derived from the hybridoma FMR2.5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Fragile X mental retardation 1 (FMR1) is encoded by the gene mapped to human chromosome Xq27.3q28. FMR1 localizes to both the nucleus and the cytoplasm.
Immunogen
synthetic peptide corresponding to a sequence at the C-terminal region of human FMR1
Application
Monoclonal Anti-FMR1 antibody produced in mouse may be used in:
- immunoblotting
- immunocytochemistry
- immunofluorescence
- flow cytometry
Biochem/physiol Actions
Fragile X mental retardation 1 (FMR1) protein functions as an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. Since, FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in nucleocytoplasmic transport. Mutation in the gene leads to the development of fragile X mental retardation (FXMR) syndrome.
Monoclonal Anti- FMR1 recognizes human, hamster, rat and mouse FMR1.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For extended storage, freeze at 20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Familial interstitial Xq27.3q28 duplication encompassing the FMR1 gene but not the MECP2 gene causes a new syndromic mental retardation condition
Rio M,et al.
European Journal of Human Genetics, 18, 285-285 (2010)
Fragile X Mental Retardation Protein FMRP Binds mRNAs in the Nucleus
Kim M, et al.
Molecular and Cellular Biology, 29, 214-228 (2009)
FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes This Association
Feng Y, et al.
Molecular Cell, 1, 109-118 (1997)
Kan Yang et al.
Cell reports, 37(5), 109939-109939 (2021-11-04)
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder, causing defects of social interaction and repetitive behaviors. Here, we identify a de novo heterozygous gene-truncating mutation of the Sentrin-specific peptidase1 (SENP1) gene in people with ASD without neurodevelopmental delay.
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